From drug delivery to environmental impact: Long-term behaviour of functionalized SBA-15 over a 20-year simulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17310%2F25%3AA2603C0I" target="_blank" >RIV/61988987:17310/25:A2603C0I - isvavai.cz</a>

Výsledek na webu

<a href="https://linkinghub.elsevier.com/retrieve/pii/S2213343725042575" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S2213343725042575</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jece.2025.119561" target="_blank" >10.1016/j.jece.2025.119561</a>

Jazyk výsledku

angličtina

Název v původním jazyce

From drug delivery to environmental impact: Long-term behaviour of functionalized SBA-15 over a 20-year simulation

Popis výsledku v původním jazyce

The long-term environmental stability of mesoporous silica is a critical yet often overlooked factor in itsapplication as a drug delivery carrier. In this study, pristine and functionalized SBA-15 with polar (amine (–NH₂),thiol (–SH), polyethylenimine (–PEI)) and non-polar (methyl (–CH₃), phenyl (–Ph)) groups were subjected toaccelerated ageing in aqueous and soil environments simulating multi-year exposure. Pristine SBA-15 exhibitedsignificant but incomplete loss of porosity (SBET decreased from 729 to 514 m² g⁻¹). Hydrophilic modificationswere least stable: SBA-15-NH₂ lost > 60 % of SBET after aqueous exposure, while SBA-15-PEI showed an apparent~16 % increase in surface area due to partial polymer leaching. In contrast, non-polar groups enhanced resilience,with SBA-15-CH₃ retaining 82 % and SBA-15-Ph 76 % of initial SBET after aqueous ageing. Soil exposureinduced more complex deterioration via ion exchange, mineral deposition, and adsorption of organic matter,with polar groups most affected. Importantly, the silica matrix remained structurally intact, demonstratingintrinsic stability. These findings highlight that functionalization strongly dictates environmental fate, withhydrophobic groups ensuring higher resilience. The results provide guidance for designing sustainable mesoporoussilica carriers with reduced environmental risks and improved regulatory compliance.

Název v anglickém jazyce

From drug delivery to environmental impact: Long-term behaviour of functionalized SBA-15 over a 20-year simulation

Popis výsledku anglicky

The long-term environmental stability of mesoporous silica is a critical yet often overlooked factor in itsapplication as a drug delivery carrier. In this study, pristine and functionalized SBA-15 with polar (amine (–NH₂),thiol (–SH), polyethylenimine (–PEI)) and non-polar (methyl (–CH₃), phenyl (–Ph)) groups were subjected toaccelerated ageing in aqueous and soil environments simulating multi-year exposure. Pristine SBA-15 exhibitedsignificant but incomplete loss of porosity (SBET decreased from 729 to 514 m² g⁻¹). Hydrophilic modificationswere least stable: SBA-15-NH₂ lost > 60 % of SBET after aqueous exposure, while SBA-15-PEI showed an apparent~16 % increase in surface area due to partial polymer leaching. In contrast, non-polar groups enhanced resilience,with SBA-15-CH₃ retaining 82 % and SBA-15-Ph 76 % of initial SBET after aqueous ageing. Soil exposureinduced more complex deterioration via ion exchange, mineral deposition, and adsorption of organic matter,with polar groups most affected. Importantly, the silica matrix remained structurally intact, demonstratingintrinsic stability. These findings highlight that functionalization strongly dictates environmental fate, withhydrophobic groups ensuring higher resilience. The results provide guidance for designing sustainable mesoporoussilica carriers with reduced environmental risks and improved regulatory compliance.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10500 - Earth and related environmental sciences

Projekt

<a href="/cs/project/LUASK22049" target="_blank" >LUASK22049: Monolitické, hierarchicky porézní MOF-uhlíkaté kompozity pro environmentální aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Environmental Chemical Engineering

ISSN

2213-2929

e-ISSN

2213-3437

Svazek periodika

—

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

001588566700001

EID výsledku v databázi Scopus

2-s2.0-105020984276