Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17450%2F20%3AA21026AQ" target="_blank" >RIV/61988987:17450/20:A21026AQ - isvavai.cz</a>
Výsledek na webu
<a href="https://journals.lww.com/menopausejournal/Abstract/2020/10000/Peripheral_vasodilation_is_reduced_during_exercise.11.aspx" target="_blank" >https://journals.lww.com/menopausejournal/Abstract/2020/10000/Peripheral_vasodilation_is_reduced_during_exercise.11.aspx</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1097/GME.0000000000001582" target="_blank" >10.1097/GME.0000000000001582</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk
Popis výsledku v původním jazyce
Objective: The menopausal transition has a negative effect on peripheral dilation in response to various stimuli including shear stress and exercise. Whether the presence of elevated traditional cardiovascular disease (CVD) risk factors in women going through menopause exacerbates the adverse effect on peripheral vasodilation is unclear. Methods: Forty-four perimenopausal women with relatively low CVD risk were divided into tertiles based on atherosclerotic CVD (ASCVD) 10-year risk scores (lowest: 0.1%-0.5%, middle: 0.6%-0.9%, higher: >1%). Comparisons were made across tertile groups for the femoral artery vascular conductance (FVC) response to single-leg knee extension exercise (0, 5, 10, 15 W) as measured using Doppler ultrasound. Results: At higher exercise intensities, FVC was lower in women in the tertile group with the highest ASCVD 10-year risk scores (10 W: 6 ± 2 mL/min/mm Hg, 15 W: 8 ± 3 mL/min/mm Hg) compared to women in the lowest tertile group (10 W: 9 ± 3 mL/min/mm Hg, P = 0.01; 15 W: 12 ± 3 mL/min/mm Hg, P < 0.01) and middle tertile group (10 W: 10 ± 4 mL/min/mm Hg, P < 0.01; 15 W: 12 ± 5 mL/min/mm Hg, P < 0.01). The overall increase in FVC during exercise from 0 to 15 W remained lower (P ≤ 0.01) in women with the highest ASCVD risk scores compared to the other two tertile groups even after adjustment for chronological age, arterial stiffness, and fat-free mass adjusted aerobic fitness level. Conclusion: Our results show that the presence of mild differences in ASCVD risk scores may be associated with a blunted active limb blood flow during leg exercise in mid-life women transitioning through menopause.
Název v anglickém jazyce
Peripheral vasodilation is reduced during exercise in perimenopausal women with elevated cardiovascular risk
Popis výsledku anglicky
Objective: The menopausal transition has a negative effect on peripheral dilation in response to various stimuli including shear stress and exercise. Whether the presence of elevated traditional cardiovascular disease (CVD) risk factors in women going through menopause exacerbates the adverse effect on peripheral vasodilation is unclear. Methods: Forty-four perimenopausal women with relatively low CVD risk were divided into tertiles based on atherosclerotic CVD (ASCVD) 10-year risk scores (lowest: 0.1%-0.5%, middle: 0.6%-0.9%, higher: >1%). Comparisons were made across tertile groups for the femoral artery vascular conductance (FVC) response to single-leg knee extension exercise (0, 5, 10, 15 W) as measured using Doppler ultrasound. Results: At higher exercise intensities, FVC was lower in women in the tertile group with the highest ASCVD 10-year risk scores (10 W: 6 ± 2 mL/min/mm Hg, 15 W: 8 ± 3 mL/min/mm Hg) compared to women in the lowest tertile group (10 W: 9 ± 3 mL/min/mm Hg, P = 0.01; 15 W: 12 ± 3 mL/min/mm Hg, P < 0.01) and middle tertile group (10 W: 10 ± 4 mL/min/mm Hg, P < 0.01; 15 W: 12 ± 5 mL/min/mm Hg, P < 0.01). The overall increase in FVC during exercise from 0 to 15 W remained lower (P ≤ 0.01) in women with the highest ASCVD risk scores compared to the other two tertile groups even after adjustment for chronological age, arterial stiffness, and fat-free mass adjusted aerobic fitness level. Conclusion: Our results show that the presence of mild differences in ASCVD risk scores may be associated with a blunted active limb blood flow during leg exercise in mid-life women transitioning through menopause.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30306 - Sport and fitness sciences
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2020
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Menopause
ISSN
1072-3714
e-ISSN
1530-0374
Svazek periodika
27
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
4
Strana od-do
1167-1170
Kód UT WoS článku
000588147200011
EID výsledku v databázi Scopus
—