Sources of inconsistency in mean mechanical response of abdominal aortic aneurysm tissue

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27230%2F21%3A10247396" target="_blank" >RIV/61989100:27230/21:10247396 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1751616120308110" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1751616120308110</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmbbm.2020.104274" target="_blank" >10.1016/j.jmbbm.2020.104274</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Sources of inconsistency in mean mechanical response of abdominal aortic aneurysm tissue

Popis výsledku v původním jazyce

Introduction: There is a striking difference in the reported mean response of abdominal aortic aneurysm tissue in academic literature depending on the type of tests (uniaxial vs biaxial) performed. In this paper, the hypothesis variability caused by differences in experimental protocols is explored using porcine aortic tissue as a substitute for aneurysmal tissue. Methods: Nine samples of porcine aorta were created and both uniaxial and biaxial tests were performed. Three effects were investigated. (i) Effect of sample (non) preconditioning, (ii) effect of objective function used (normalised vs non-normalised), and (iii) effect of chosen procedure used for mean response calculation: constant averaging (CA) vs fit to averaged response (FAR) vs fit to all data (FAD). Both the overall shape of mean curve and mean initial stiffness were compared. Results: (i) Non-preconditioning led to a much stiffer response, and initial stiffness was about three times higher for a non-preconditioned response based on uniaxial data compared to a preconditioned biaxial response. (ii) CA led to a much stiffer response compared to FAR and FAD procedures which gave similar results. (iii) Normalised objective function produced a mean response with six times lower initial stiffness and more pronounced nonlinearity compared to non-normalised objective function. Discussion: It is possible to reproduce a mechanically inconsistent response purely by using the chosen experimental protocol. Non-preconditioned data from failure tests should be used for FE simulation of the elastic response of aneurysms. CA should not be used to obtain a mean response.

Název v anglickém jazyce

Sources of inconsistency in mean mechanical response of abdominal aortic aneurysm tissue

Popis výsledku anglicky

Introduction: There is a striking difference in the reported mean response of abdominal aortic aneurysm tissue in academic literature depending on the type of tests (uniaxial vs biaxial) performed. In this paper, the hypothesis variability caused by differences in experimental protocols is explored using porcine aortic tissue as a substitute for aneurysmal tissue. Methods: Nine samples of porcine aorta were created and both uniaxial and biaxial tests were performed. Three effects were investigated. (i) Effect of sample (non) preconditioning, (ii) effect of objective function used (normalised vs non-normalised), and (iii) effect of chosen procedure used for mean response calculation: constant averaging (CA) vs fit to averaged response (FAR) vs fit to all data (FAD). Both the overall shape of mean curve and mean initial stiffness were compared. Results: (i) Non-preconditioning led to a much stiffer response, and initial stiffness was about three times higher for a non-preconditioned response based on uniaxial data compared to a preconditioned biaxial response. (ii) CA led to a much stiffer response compared to FAR and FAD procedures which gave similar results. (iii) Normalised objective function produced a mean response with six times lower initial stiffness and more pronounced nonlinearity compared to non-normalised objective function. Discussion: It is possible to reproduce a mechanically inconsistent response purely by using the chosen experimental protocol. Non-preconditioned data from failure tests should be used for FE simulation of the elastic response of aneurysms. CA should not be used to obtain a mean response.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

<a href="/cs/project/LTAUSA18134" target="_blank" >LTAUSA18134: Výpočtově statistické hodnocení rizika ruptury aneurysmat abdominální aorty</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Mechanical Behavior of Biomedical Materials

ISSN

1751-6161

e-ISSN

—

Svazek periodika

115

Číslo periodika v rámci svazku

březen

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

—

Kód UT WoS článku

000618729800002

EID výsledku v databázi Scopus

—