Modeling a neurological disorder as the result of an operator acting on the brain: A first sketch based on network channel modeling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27240%2F24%3A10257613" target="_blank" >RIV/61989100:27240/24:10257613 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.aip.org/aip/cha/article-abstract/34/5/053133/3294604/Modeling-a-neurological-disorder-as-the-result-of?redirectedFrom=fulltext" target="_blank" >https://pubs.aip.org/aip/cha/article-abstract/34/5/053133/3294604/Modeling-a-neurological-disorder-as-the-result-of?redirectedFrom=fulltext</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1063/5.0199988" target="_blank" >10.1063/5.0199988</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Modeling a neurological disorder as the result of an operator acting on the brain: A first sketch based on network channel modeling

Popis výsledku v původním jazyce

The brain is a complex network, and diseases can alter its structures and connections between regions. Therefore, we can try to formalize the action of diseases by using operators acting on the brain network. Here, we propose a conceptual model of the brain, seen as a multilayer network, whose intra-lobe interactions are formalized as the diagonal blocks of an adjacency matrix. We propose a general and abstract definition of disease as an operator altering the weights of the connections between neural agglomerates, that is, the elements of the brain matrix. As models, we consider examples from three neurological disorders: epilepsy, Alzheimer-Perusini&apos;s disease, and schizophrenia. The alteration of neural connections can be seen as alterations of communication pathways, and thus, they can be described with a new channel model.

Název v anglickém jazyce

Modeling a neurological disorder as the result of an operator acting on the brain: A first sketch based on network channel modeling

Popis výsledku anglicky

The brain is a complex network, and diseases can alter its structures and connections between regions. Therefore, we can try to formalize the action of diseases by using operators acting on the brain network. Here, we propose a conceptual model of the brain, seen as a multilayer network, whose intra-lobe interactions are formalized as the diagonal blocks of an adjacency matrix. We propose a general and abstract definition of disease as an operator altering the weights of the connections between neural agglomerates, that is, the elements of the brain matrix. As models, we consider examples from three neurological disorders: epilepsy, Alzheimer-Perusini&apos;s disease, and schizophrenia. The alteration of neural connections can be seen as alterations of communication pathways, and thus, they can be described with a new channel model.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

10102 - Applied mathematics

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chaos

ISSN

1054-1500

e-ISSN

1089-7682

Svazek periodika

34

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

15

Strana od-do

nestránkováno

Kód UT WoS článku

001231939100001

EID výsledku v databázi Scopus

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