Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F18%3A10239148" target="_blank" >RIV/61989100:27350/18:10239148 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.expresspolymlett.com/index.html?tartalom=content.php&year=2018&number=1&kodnumber=1" target="_blank" >http://www.expresspolymlett.com/index.html?tartalom=content.php&year=2018&number=1&kodnumber=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3144/expresspolymlett.2018.8" target="_blank" >10.3144/expresspolymlett.2018.8</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing

Popis výsledku v původním jazyce

Application of human mesenchymal stem cells brings a new hope for advanced wound healing. To enable cells culture and their viability maintenance, a new type of biomaterials must be developed. Scaffolds prepared from polymers of natural origin can mimic extracellular matrix. Chitosan, which is a chitin derivative, has many favorable properties like biodegradability or lack of cytotoxicity. Therefore, it is widely applied in medicine and pharmacy. Nevertheless, its chemical modification may lead to the loss of biocompatibility of the material and generate some significant problems with cells culture. In this article a novel strategy of the bioactive and antimicrobial chitosan hydrogel scaffolds is presented. As crosslinking agents non-toxic substances were used such as aspartic acid and glutamic acid. Obtained biomaterials were investigated over their chemical structure, morphology and biological activity. Performed tests using human mesenchymal stem cells confirmed bioactivity and biocompatibility, as well as antibacterial and antifungal properties.

Název v anglickém jazyce

Chitosan/aminoacid hydrogels with antimicrobial and bioactive properties as new scaffolds for human mesenchymal stem cells culture applicable in wound healing

Popis výsledku anglicky

Application of human mesenchymal stem cells brings a new hope for advanced wound healing. To enable cells culture and their viability maintenance, a new type of biomaterials must be developed. Scaffolds prepared from polymers of natural origin can mimic extracellular matrix. Chitosan, which is a chitin derivative, has many favorable properties like biodegradability or lack of cytotoxicity. Therefore, it is widely applied in medicine and pharmacy. Nevertheless, its chemical modification may lead to the loss of biocompatibility of the material and generate some significant problems with cells culture. In this article a novel strategy of the bioactive and antimicrobial chitosan hydrogel scaffolds is presented. As crosslinking agents non-toxic substances were used such as aspartic acid and glutamic acid. Obtained biomaterials were investigated over their chemical structure, morphology and biological activity. Performed tests using human mesenchymal stem cells confirmed bioactivity and biocompatibility, as well as antibacterial and antifungal properties.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Express Polymer Letters

ISSN

1788-618X

e-ISSN

—

Svazek periodika

12

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

HU - Maďarsko

Počet stran výsledku

13

Strana od-do

100-112

Kód UT WoS článku

000417024000008

EID výsledku v databázi Scopus

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