Microwave-assisted synthesis and characterization of antibacterial O-crosslinked chitosan hydrogels doped with TiO2 nanoparticles for skin regeneration

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F19%3A10240382" target="_blank" >RIV/61989100:27350/19:10240382 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/abs/10.1080/00914037.2018.1517351" target="_blank" >https://www.tandfonline.com/doi/abs/10.1080/00914037.2018.1517351</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00914037.2018.1517351" target="_blank" >10.1080/00914037.2018.1517351</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Microwave-assisted synthesis and characterization of antibacterial O-crosslinked chitosan hydrogels doped with TiO2 nanoparticles for skin regeneration

Popis výsledku v původním jazyce

Tissue engineering provides alternative solutions to traditional transplantation. In this study a novel strategy of chitosan scaffolds obtainment based on selective O-crosslinking using Aspartic acid and the addition of TiO2 nanoparticles is presented. Prepared under microwave conditions biomaterials were of increased mechanical and thermal durability thanks to NPs presence comparing to pure chitosan. Moreover porous scaffolds maintained antimicrobial activity against S. Aureus and E. Coli. Biomaterials were susceptible to in vitro biodegradation and degradation. Hydrogels exhibited positive impact on proliferation activity of fibroblasts. Thus they may be applied as 3D scaffolds in tissue engineering focused on wound healing. (C) 2018, (C) 2018 Taylor &amp; Francis.

Název v anglickém jazyce

Microwave-assisted synthesis and characterization of antibacterial O-crosslinked chitosan hydrogels doped with TiO2 nanoparticles for skin regeneration

Popis výsledku anglicky

Tissue engineering provides alternative solutions to traditional transplantation. In this study a novel strategy of chitosan scaffolds obtainment based on selective O-crosslinking using Aspartic acid and the addition of TiO2 nanoparticles is presented. Prepared under microwave conditions biomaterials were of increased mechanical and thermal durability thanks to NPs presence comparing to pure chitosan. Moreover porous scaffolds maintained antimicrobial activity against S. Aureus and E. Coli. Biomaterials were susceptible to in vitro biodegradation and degradation. Hydrogels exhibited positive impact on proliferation activity of fibroblasts. Thus they may be applied as 3D scaffolds in tissue engineering focused on wound healing. (C) 2018, (C) 2018 Taylor &amp; Francis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Polymeric Materials and Polymeric Biomaterials

ISSN

0091-4037

e-ISSN

—

Svazek periodika

68

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000472755300001

EID výsledku v databázi Scopus

2-s2.0-85054846052