Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behaviour

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F22%3A10250247" target="_blank" >RIV/61989100:27350/22:10250247 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27730/22:10250247

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0032591022004193" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022004193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2022.117525" target="_blank" >10.1016/j.powtec.2022.117525</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behaviour

Popis výsledku v původním jazyce

Hard gelatine capsules remain a relevant dosage form for today&apos;s pharmaceutical manufacturing. A wide range of colour and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various modern dosage forms and combinations thereof may affect their further processing. Therefore, a detailed study was carried out to assess the effect of mechanical-physical properties on the behaviour of differently filled hard gelatine capsules. Capsules filled with powder, free or fixed particles presenting drug microforms and also hard gelatine capsules themselves were evaluated. Basic mechanical-physical characterisation was performed on all samples. Furthermore, their transport on the vibrating conveyor was assessed and simulated using DEM. The results showed a significant influence mainly by the degree of capsule imbalance, i.e., the arrangement of particles in the capsule. It was found that the hard gelatine capsules showed an average of 15.6o lower values for the effective angle of internal friction compared to the powdered vitamin mixture, and in parallel, an average of 14.7o lower values for the static angle of repose were also recorded. The results of the experiments on the vibrating conveyor at a frequency setting of 15 Hz showed three times longer transport time for the vitamin mixture compared to the capsules. Increasing the frequency evened out these differences. (C) 2022 Elsevier B.V.

Název v anglickém jazyce

Hard gelatine capsules: DEM supported experimental study of particle arrangement effect on properties and vibrational transport behaviour

Popis výsledku anglicky

Hard gelatine capsules remain a relevant dosage form for today&apos;s pharmaceutical manufacturing. A wide range of colour and print options supports marketing, brand image and patient loyalty. However, the filling of these capsules with various modern dosage forms and combinations thereof may affect their further processing. Therefore, a detailed study was carried out to assess the effect of mechanical-physical properties on the behaviour of differently filled hard gelatine capsules. Capsules filled with powder, free or fixed particles presenting drug microforms and also hard gelatine capsules themselves were evaluated. Basic mechanical-physical characterisation was performed on all samples. Furthermore, their transport on the vibrating conveyor was assessed and simulated using DEM. The results showed a significant influence mainly by the degree of capsule imbalance, i.e., the arrangement of particles in the capsule. It was found that the hard gelatine capsules showed an average of 15.6o lower values for the effective angle of internal friction compared to the powdered vitamin mixture, and in parallel, an average of 14.7o lower values for the static angle of repose were also recorded. The results of the experiments on the vibrating conveyor at a frequency setting of 15 Hz showed three times longer transport time for the vitamin mixture compared to the capsules. Increasing the frequency evened out these differences. (C) 2022 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20402 - Chemical process engineering

Projekt

<a href="/cs/project/EF19_073%2F0016945" target="_blank" >EF19_073/0016945: Doktorská grantová soutěž VŠB - TU Ostrava</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder technology

ISSN

0032-5910

e-ISSN

1873-328X

Svazek periodika

405

Číslo periodika v rámci svazku

117525

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

19

Strana od-do

nestrankovano

Kód UT WoS článku

000809689300003

EID výsledku v databázi Scopus

2-s2.0-85130794088