Grain Size and Electrochemical Surface Modification Effects on Corrosion, Biological, and Technological Properties of CP Titanium Implants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27350%2F25%3A10259679" target="_blank" >RIV/61989100:27350/25:10259679 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11140/25:10507395 RIV/61989100:27360/25:10259679 RIV/61989100:27730/25:10259679

Výsledek na webu

<a href="https://www.mdpi.com/2079-4983/16/12/439" target="_blank" >https://www.mdpi.com/2079-4983/16/12/439</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/jfb16120439" target="_blank" >10.3390/jfb16120439</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Grain Size and Electrochemical Surface Modification Effects on Corrosion, Biological, and Technological Properties of CP Titanium Implants

Popis výsledku v původním jazyce

Commercially pure (CP) titanium is widely used for long-term biomedical implants due to its high biocompatibility and corrosion resistance. However, its relatively low strength limits its use in highly loaded applications. Ultrafine-grained (UFG) titanium obtained through severe plastic deformation offers enhanced mechanical performance while maintaining the stability of CP titanium. This study investigates how electrochemical surface modification by anodization affects the corrosion, biological performance, and technological behavior of UFG titanium. TiO2 layers with nanotubular and nanoporous morphologies were produced at anodization voltages between 20 and 60 V. Corrosion tests in physiological solution confirmed stable passive behavior with corrosion rates below 4 mu m year-1, and surface wettability increased markedly with anodization. Osteoblast-like MG-63 cells exhibited good viability on all anodized surfaces, with improved adhesion and proliferation on samples anodized at 60 V. The porous TiO2 layers were successfully intercalated with dimethyl sulfoxide and ibuprofen, demonstrating potential for local drug delivery. Implantation simulations on real Nanoimplant (R) prototypes confirmed sufficient mechanical stability of the anodized layer. Overall, the optimized anodization of UFG titanium enhances its biological response while maintaining corrosion resistance, supporting its clinical use in long-term dental and orthopedic implants with integrated drug-release functionality.

Název v anglickém jazyce

Grain Size and Electrochemical Surface Modification Effects on Corrosion, Biological, and Technological Properties of CP Titanium Implants

Popis výsledku anglicky

Commercially pure (CP) titanium is widely used for long-term biomedical implants due to its high biocompatibility and corrosion resistance. However, its relatively low strength limits its use in highly loaded applications. Ultrafine-grained (UFG) titanium obtained through severe plastic deformation offers enhanced mechanical performance while maintaining the stability of CP titanium. This study investigates how electrochemical surface modification by anodization affects the corrosion, biological performance, and technological behavior of UFG titanium. TiO2 layers with nanotubular and nanoporous morphologies were produced at anodization voltages between 20 and 60 V. Corrosion tests in physiological solution confirmed stable passive behavior with corrosion rates below 4 mu m year-1, and surface wettability increased markedly with anodization. Osteoblast-like MG-63 cells exhibited good viability on all anodized surfaces, with improved adhesion and proliferation on samples anodized at 60 V. The porous TiO2 layers were successfully intercalated with dimethyl sulfoxide and ibuprofen, demonstrating potential for local drug delivery. Implantation simulations on real Nanoimplant (R) prototypes confirmed sufficient mechanical stability of the anodized layer. Overall, the optimized anodization of UFG titanium enhances its biological response while maintaining corrosion resistance, supporting its clinical use in long-term dental and orthopedic implants with integrated drug-release functionality.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

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OECD FORD obor

20501 - Materials engineering

Projekt

<a href="/cs/project/EH22_008%2F0004631" target="_blank" >EH22_008/0004631: Materiály a technologie pro udržitelný rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Functional Biomaterials

ISSN

2079-4983

e-ISSN

2079-4983

Svazek periodika

16

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

26

Strana od-do

nestránkováno

Kód UT WoS článku

001646818800001

EID výsledku v databázi Scopus

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