Polymeric Nanocomposite with Antibacterial and Antitumoral Particles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27360%2F16%3A86099188" target="_blank" >RIV/61989100:27360/16:86099188 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27640/16:86099188 RIV/61989100:27740/16:86099188

Výsledek na webu

<a href="http://dx.doi.org/10.1166/asl.2016.6990" target="_blank" >http://dx.doi.org/10.1166/asl.2016.6990</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1166/asl.2016.6990" target="_blank" >10.1166/asl.2016.6990</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polymeric Nanocomposite with Antibacterial and Antitumoral Particles

Popis výsledku v původním jazyce

The aim of this research work was to find out the suitability of selected polymeric matrices for the further studies of nanocomposites with antibacterial and antitumoral properties to use it in medicine. The selected for the study biodegradable triblock copolymers are polycaprolactone polyethylene glycol polycaprolactone (PCL-PEG-PCL) and polycaprolactone polyglycolic acid polycaprolactone (PCL-PGA-PCL) and as an antitumoral drug, Erlotinib was chosen. By means of molecular modeling, it was found that for both matrices, the bigger amount of drug is a reason of growing of cohesive energy density (CED). It means that the system is more stable having greater amount of drug. The case of polyethylene glycol (PEG) and polyglycolic acid (PGA) the data showed lower values of CED for PCL-PEG-PCL matrix the findings may indicate stronger interaction between Erlotinib and PGA than with PEG. This work is a first step for understanding the advantages and disadvantages of various materials for medical using.

Název v anglickém jazyce

Polymeric Nanocomposite with Antibacterial and Antitumoral Particles

Popis výsledku anglicky

The aim of this research work was to find out the suitability of selected polymeric matrices for the further studies of nanocomposites with antibacterial and antitumoral properties to use it in medicine. The selected for the study biodegradable triblock copolymers are polycaprolactone polyethylene glycol polycaprolactone (PCL-PEG-PCL) and polycaprolactone polyglycolic acid polycaprolactone (PCL-PGA-PCL) and as an antitumoral drug, Erlotinib was chosen. By means of molecular modeling, it was found that for both matrices, the bigger amount of drug is a reason of growing of cohesive energy density (CED). It means that the system is more stable having greater amount of drug. The case of polyethylene glycol (PEG) and polyglycolic acid (PGA) the data showed lower values of CED for PCL-PEG-PCL matrix the findings may indicate stronger interaction between Erlotinib and PGA than with PEG. This work is a first step for understanding the advantages and disadvantages of various materials for medical using.

Druh

D - Stať ve sborníku

CEP obor

JI - Kompositní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Advanced Science Letters : 4th Biennial Nanomaterials and Nanotechnology International Conference : proceedings : May 18-21, 2015, Ostrava, Czech Republic

ISBN

—

ISSN

1936-6612

e-ISSN

—

Počet stran výsledku

3

Strana od-do

685-687

Název nakladatele

American Scientific Publishers

Místo vydání

Valencia

Místo konání akce

Ostrava

Datum konání akce

18. 5. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000381233100019