Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F12%3A86084643" target="_blank" >RIV/61989100:27640/12:86084643 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study

Popis výsledku v původním jazyce

Molecular modeling is nowadays routinely employed in many branches of science and pharmaceutical chemistry is not an exception. This modeling study was focused on behavior of amphiphilic gels mixture serving as a carriers of drug cyclosporine A (CsA) andthe main aim was to find whether the contact with small amount of paraffin oil during the production can affect this behavior. Two systems were studied in Accelrys Materials Studio modeling environment: (1) pure gel-based CsA carrier and (2) gel-based drug carrier with small amount of paraffin oil added (~ 4 wt.%). The attention has been paid mainly to the homogeneity of CsA/gel clusters, pervasion of water into clusters and energy characteristics of clusters. It was found that the presence of small amount of paraffin oil does not affect the behavior of carrier.

Název v anglickém jazyce

Influence of paraffin oil on behavior of gel-based drug carrier: molecular modeling study

Popis výsledku anglicky

Molecular modeling is nowadays routinely employed in many branches of science and pharmaceutical chemistry is not an exception. This modeling study was focused on behavior of amphiphilic gels mixture serving as a carriers of drug cyclosporine A (CsA) andthe main aim was to find whether the contact with small amount of paraffin oil during the production can affect this behavior. Two systems were studied in Accelrys Materials Studio modeling environment: (1) pure gel-based CsA carrier and (2) gel-based drug carrier with small amount of paraffin oil added (~ 4 wt.%). The attention has been paid mainly to the homogeneity of CsA/gel clusters, pervasion of water into clusters and energy characteristics of clusters. It was found that the presence of small amount of paraffin oil does not affect the behavior of carrier.

Druh

D - Stať ve sborníku

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/ED1.1.00%2F02.0070" target="_blank" >ED1.1.00/02.0070: Centrum excelence IT4Innovations</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2012 : 4th international conference : conference proceedings : October 23rd-25th 2012, hotel Voroněž I, Brno, Czech Republic, EU

ISBN

978-80-87294-35-2

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

564-568

Název nakladatele

Tanger

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

23. 10. 2012

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

000333697100103