METAL AND CARBON-BASED PARTICLES / CLUSTERS IN THE PERIPHERAL T - CELL LYMPHOMA IN THE LUNGS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F15%3A86099737" target="_blank" >RIV/61989100:27640/15:86099737 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989100:27740/15:86099737

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

METAL AND CARBON-BASED PARTICLES / CLUSTERS IN THE PERIPHERAL T - CELL LYMPHOMA IN THE LUNGS

Popis výsledku v původním jazyce

Submicron particles occurring in the environment are of natural origin, but are also formed by anthropogenic activities as secondary products. The source of these submicron particles are e.g. energy industries, ore processing, cosmetic and pharmaceutical industries, smoking, transportation, etc. Chemical composition of these particles from single sources is not precisely known. Due to their size (<1 mu m) they can be easily inhaled and thus enter deep respiratory tract into the lungs. Depending on their size and chemical composition they may have the ability to induce oxidative stress in cells, which lead to damage to the body eventually. The paper addresses occurrence of unspecified peripheral T-cell lymphoma in a 74-year-old male patient, non-smoker, previously working in metal rollers worker. This case was evaluated from the pathological point of view, together with a detection of submicron particles/clusters in the sample of the tumor tissue. Histologically the tumor was in lung tissue inaccurately bounded with diffusely growing medium sized to large lymphoid elements having nuclei of irregular size and shape and with one or multiple nucleoli with prominent mitotic activity. Dark pigment was also dispersed in the tissue during examination by light microscopy at high magnification under polarized light and also foreign particles probably of metallic character were observed. Experimental method used included scanning electron microscopy with energy dispersive spectroscopy (SEM -EDX) and Raman microspectroscopy. SEM - EDX revealed presence of particles/clusters in sizes <500 nm based mainly on iron. Occurrence of iron particles namely siderite (FeCO3) was confirmed by Raman microspectroscopy. Moreover the tumor tissue was identified to contain carbon black and graphite-based particles.

Název v anglickém jazyce

METAL AND CARBON-BASED PARTICLES / CLUSTERS IN THE PERIPHERAL T - CELL LYMPHOMA IN THE LUNGS

Popis výsledku anglicky

Submicron particles occurring in the environment are of natural origin, but are also formed by anthropogenic activities as secondary products. The source of these submicron particles are e.g. energy industries, ore processing, cosmetic and pharmaceutical industries, smoking, transportation, etc. Chemical composition of these particles from single sources is not precisely known. Due to their size (<1 mu m) they can be easily inhaled and thus enter deep respiratory tract into the lungs. Depending on their size and chemical composition they may have the ability to induce oxidative stress in cells, which lead to damage to the body eventually. The paper addresses occurrence of unspecified peripheral T-cell lymphoma in a 74-year-old male patient, non-smoker, previously working in metal rollers worker. This case was evaluated from the pathological point of view, together with a detection of submicron particles/clusters in the sample of the tumor tissue. Histologically the tumor was in lung tissue inaccurately bounded with diffusely growing medium sized to large lymphoid elements having nuclei of irregular size and shape and with one or multiple nucleoli with prominent mitotic activity. Dark pigment was also dispersed in the tissue during examination by light microscopy at high magnification under polarized light and also foreign particles probably of metallic character were observed. Experimental method used included scanning electron microscopy with energy dispersive spectroscopy (SEM -EDX) and Raman microspectroscopy. SEM - EDX revealed presence of particles/clusters in sizes <500 nm based mainly on iron. Occurrence of iron particles namely siderite (FeCO3) was confirmed by Raman microspectroscopy. Moreover the tumor tissue was identified to contain carbon black and graphite-based particles.

Druh

D - Stať ve sborníku

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

<a href="/cs/project/LO1203" target="_blank" >LO1203: Regionální materiálově technologické výzkumné centrum - Program udržitelnosti</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2015: 7th international conference : proceedings of abstracts

ISBN

978-80-87294-59-8

ISSN

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e-ISSN

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Počet stran výsledku

558

Strana od-do

553

Název nakladatele

Tanger

Místo vydání

Ostrava

Místo konání akce

Brno

Datum konání akce

14. 10. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000374708800097