Adhesive antibacterial coatings based on copolymers bearing thiazolium cationic groups and catechol moieties as robust anchors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F19%3A10242933" target="_blank" >RIV/61989100:27640/19:10242933 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0300944019305247" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0300944019305247</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.porgcoat.2019.105272" target="_blank" >10.1016/j.porgcoat.2019.105272</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Adhesive antibacterial coatings based on copolymers bearing thiazolium cationic groups and catechol moieties as robust anchors

Popis výsledku v původním jazyce

Herein, we describe a simple approach for the preparation of antibacterial polymeric coatings based on mussel inspired catechol chemistry. A series of statistical copolymers composed of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) and N-(3,4-dihydroxyphenethyl) methacrylamide (DOMA) were synthesized by conventional free radical and reversible addition fragmentation chain transfer (RAFT) polymerizations. Subsequently, the thiazole groups of MTA units were quatemized with methyl and butyl iodide as alkylating agents to provide cationic copolymers with also adhesive anchoring groups of catechol. The copolymers were systematically studied to investigate the effects of composition (MTA/DOMA ratio), molecular weight and alkylating agent on adhesive and antibacterial properties. It was proved that DOMA units play a major role in the adhesion, while the antibacterial activity only decreases slightly with content of DOMA up to 32%. Remarkable, for similar MTA molar equivalent, the copolymers with higher molecular weight exhibit better antimicrobial properties in solution, whereas when they are tethered onto a surface as a coating, the copolymers with lower molecular weight showed enhanced antibacterial performance even against Gram-negative bacteria. These findings confirm that antimicrobial polymers attached onto surfaces behave in a different manner than in solution, and can be more effective as the mobility and accessibility of the cationic groups increase.

Název v anglickém jazyce

Adhesive antibacterial coatings based on copolymers bearing thiazolium cationic groups and catechol moieties as robust anchors

Popis výsledku anglicky

Herein, we describe a simple approach for the preparation of antibacterial polymeric coatings based on mussel inspired catechol chemistry. A series of statistical copolymers composed of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) and N-(3,4-dihydroxyphenethyl) methacrylamide (DOMA) were synthesized by conventional free radical and reversible addition fragmentation chain transfer (RAFT) polymerizations. Subsequently, the thiazole groups of MTA units were quatemized with methyl and butyl iodide as alkylating agents to provide cationic copolymers with also adhesive anchoring groups of catechol. The copolymers were systematically studied to investigate the effects of composition (MTA/DOMA ratio), molecular weight and alkylating agent on adhesive and antibacterial properties. It was proved that DOMA units play a major role in the adhesion, while the antibacterial activity only decreases slightly with content of DOMA up to 32%. Remarkable, for similar MTA molar equivalent, the copolymers with higher molecular weight exhibit better antimicrobial properties in solution, whereas when they are tethered onto a surface as a coating, the copolymers with lower molecular weight showed enhanced antibacterial performance even against Gram-negative bacteria. These findings confirm that antimicrobial polymers attached onto surfaces behave in a different manner than in solution, and can be more effective as the mobility and accessibility of the cationic groups increase.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20506 - Coating and films

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Progress in Organic Coatings

ISSN

0300-9440

e-ISSN

—

Svazek periodika

136

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

000490030200080

EID výsledku v databázi Scopus

2-s2.0-85072243438