A general atomically dispersed copper catalyst for C-O, C-N, and C-C bond formation by carbene insertion reactions
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989100%3A27640%2F24%3A10255075" target="_blank" >RIV/61989100:27640/24:10255075 - isvavai.cz</a>
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/abs/pii/S2451929424000834?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S2451929424000834?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.chempr.2024.02.021" target="_blank" >10.1016/j.chempr.2024.02.021</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A general atomically dispersed copper catalyst for C-O, C-N, and C-C bond formation by carbene insertion reactions
Popis výsledku v původním jazyce
The implementation of heterogeneous catalysts in advanced organic synthesis provides basis for the sustainable and cost-effective preparation of pharmaceuticals, agrochemicals, and other structurally complex molecules. Crucial for such applications is the design of appropriate catalytic materials with high selectivity and functional group compatibility. Although many homogeneous catalysts are well known for this purpose, heterogeneous ones, specifically those based on non-noble metals, are scarce. Here, we present the preparation and wide-ranging applications of a specific atomically dispersed copper catalyst for highly selective carbene insertion reactions of diazo compounds with alcohols, phenols, amines, thiols, and N-heterocycles. The optimal catalyst (Cu-NC/Al2O3) contains Al2O3-supported copper-based single atoms coordinated with nitrogen species, which can be conveniently prepared by the pyrolysis of Cu-MOF-303. The resulting catalyst allows for the selective formation of C-O, C-N, and C-C bonds in functionalized and structurally diverse molecules (e.g., complex natural products and drugs), including highly sensitive alkynes and azides. (C) 2024 Elsevier Inc.
Název v anglickém jazyce
A general atomically dispersed copper catalyst for C-O, C-N, and C-C bond formation by carbene insertion reactions
Popis výsledku anglicky
The implementation of heterogeneous catalysts in advanced organic synthesis provides basis for the sustainable and cost-effective preparation of pharmaceuticals, agrochemicals, and other structurally complex molecules. Crucial for such applications is the design of appropriate catalytic materials with high selectivity and functional group compatibility. Although many homogeneous catalysts are well known for this purpose, heterogeneous ones, specifically those based on non-noble metals, are scarce. Here, we present the preparation and wide-ranging applications of a specific atomically dispersed copper catalyst for highly selective carbene insertion reactions of diazo compounds with alcohols, phenols, amines, thiols, and N-heterocycles. The optimal catalyst (Cu-NC/Al2O3) contains Al2O3-supported copper-based single atoms coordinated with nitrogen species, which can be conveniently prepared by the pyrolysis of Cu-MOF-303. The resulting catalyst allows for the selective formation of C-O, C-N, and C-C bonds in functionalized and structurally diverse molecules (e.g., complex natural products and drugs), including highly sensitive alkynes and azides. (C) 2024 Elsevier Inc.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10400 - Chemical sciences
Návaznosti výsledku
Projekt
—
Návaznosti
O - Projekt operacniho programu
Ostatní
Rok uplatnění
2024
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Chem
ISSN
2451-9308
e-ISSN
—
Svazek periodika
10
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
13
Strana od-do
1897-1909
Kód UT WoS článku
001254183200001
EID výsledku v databázi Scopus
2-s2.0-85189653200