Chemoprotektivní vliv rostlinných fenolů vůči toxicitě indukované anthracyklinem u potkaních kardiomyocytů. Část II. Silymarin a jeho flavonolignany

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000787" target="_blank" >RIV/61989592:15110/04:00000787 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

Popis výsledku v původním jazyce

Silymarin, an extract of flavonolignans from the dried fruits of milk thistle (Silybum marianum L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were tested for protective effects on rat cardiomyocytes exposed to doxorubicin. Silymarin and individual flavonolignans did not exert cytotoxicity in the range 25-100 #m (incubation 9 h). Dehydrosilibinin was tested only at 25 #m concentration due to its low solubility. All substances increased the cell ATP level. Silymarin and flavonolignans displayed a dose-dependent cytoprotection against doxorubicin (100 #m, incubation 8 h). The protective effects of silymarin, silibinin, dehydrosilibinin and silychristin were comparable to that of dexrasoxane, while silydianin exerted the best protective effect. The ability of silymarin complex and its components to protect cardiomyocytes against doxorubicin-induced oxidative stress is due mainly to their cell membrane stabilization effect, radical scavenging an

Název v anglickém jazyce

Chemoprotective effect of plant phenolics against anthracycline-induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

Popis výsledku anglicky

Silymarin, an extract of flavonolignans from the dried fruits of milk thistle (Silybum marianum L. Gaertneri) and its constituents silibinin, dehydrosilibinin, silychristin and silydianin were tested for protective effects on rat cardiomyocytes exposed to doxorubicin. Silymarin and individual flavonolignans did not exert cytotoxicity in the range 25-100 #m (incubation 9 h). Dehydrosilibinin was tested only at 25 #m concentration due to its low solubility. All substances increased the cell ATP level. Silymarin and flavonolignans displayed a dose-dependent cytoprotection against doxorubicin (100 #m, incubation 8 h). The protective effects of silymarin, silibinin, dehydrosilibinin and silychristin were comparable to that of dexrasoxane, while silydianin exerted the best protective effect. The ability of silymarin complex and its components to protect cardiomyocytes against doxorubicin-induced oxidative stress is due mainly to their cell membrane stabilization effect, radical scavenging an

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Phytotherapy Research

ISSN

0951-418X

e-ISSN

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Svazek periodika

18

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

107-110

Kód UT WoS článku

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EID výsledku v databázi Scopus

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