Rekombinantní proteiny a DNA vakcíny derivované z hsp 60 Trichophyton mentagrophytes ovlivňují klinický průběh trichophytózy u krav a morčat

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000836" target="_blank" >RIV/61989592:15110/04:00000836 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/04:00006164

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs

Popis výsledku v původním jazyce

Heat shock proteins (hsp) were identified in many infectious agents asimmunodominant antigens with a protective effect. Immunization of laboratoryanimals by selected representants of hsp60, hsp70 and hsp90 isolated from severalpathogens induced protective host immunity and significantly reduced clinicalmanifestation of infection. The present study involves preparation of a recombinantprotein vaccine and a DNA vaccine. Both vaccines were derived from the hsp60 of thedermatophyte, Trichophyton mentagrophytes. Challenge trials with evaluation of theprotective effect of vaccination were performed on calves and guinea-pigs. Bothvaccination procedures reduced, in statistically significant fashion, the clinical courseof skin mycosis in calves experimentally inoculated with the dermatophyte,T. mentagrophytes. In experiments with guinea-pigs, increased protection was onlyseen with DNA vaccination. After DNA vaccine application, no paravaccination sideeffects(granulomas at the injection

Název v anglickém jazyce

Recombinant protein and DNA vaccines derived from hsp60 Trichophyton mentagrophytes control the clinical course of trichophytosis in bovine species and guinea-pigs

Popis výsledku anglicky

Heat shock proteins (hsp) were identified in many infectious agents asimmunodominant antigens with a protective effect. Immunization of laboratoryanimals by selected representants of hsp60, hsp70 and hsp90 isolated from severalpathogens induced protective host immunity and significantly reduced clinicalmanifestation of infection. The present study involves preparation of a recombinantprotein vaccine and a DNA vaccine. Both vaccines were derived from the hsp60 of thedermatophyte, Trichophyton mentagrophytes. Challenge trials with evaluation of theprotective effect of vaccination were performed on calves and guinea-pigs. Bothvaccination procedures reduced, in statistically significant fashion, the clinical courseof skin mycosis in calves experimentally inoculated with the dermatophyte,T. mentagrophytes. In experiments with guinea-pigs, increased protection was onlyseen with DNA vaccination. After DNA vaccine application, no paravaccination sideeffects(granulomas at the injection

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FN - Epidemiologie, infekční nemoci a klinická imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NI7538" target="_blank" >NI7538: Srovnání protektivního efektu hsp90 rekombinantní proteinové a DNA vakcinace myší u modelové systémové a vaginální kandidózy.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mycoses

ISSN

0943-7312

e-ISSN

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Svazek periodika

47

Číslo periodika v rámci svazku

9-10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

407-417

Kód UT WoS článku

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EID výsledku v databázi Scopus

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