Vliv estrogen-progestinové substituce na expresi estrogenových a progesteronových receptorů a apoptózu v lidském endometriu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F04%3A00000918" target="_blank" >RIV/61989592:15110/04:00000918 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/04:00002040

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM

Popis výsledku v původním jazyce

Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substitu

Název v anglickém jazyce

THE IMPACT OF ORAL ESTRADIOL AND PROGESTERONE SUBSTITUTION ON ESTROGEN AND PROGESTERONE RECEPTORS EXPRESSION AND APOPTOSIS IN HUMAN ENDOMETRIUM

Popis výsledku anglicky

Objective: Exogenous hormonal manipulation may alter physiological cyclic pattern of endometrium. This article evaluates the effect of oral estrogen-progesterone substitution on the expression of estrogen and progesterone receptors and the level of apoptosis in the secretory endometrium of substituted cycles by comparison with natural cycles in the same patient.Methods: Serum levels of estradiol (E2), SHBG and progesterone (P) were determined and bioptic samples of endometrium were taken on the 5th and7th day of luteal phase in 26 infertile women who entered the assisted reproduction program first in a spontaneous and later in an estrogen-progestagen substituted cycle. E and P receptors (ER and PR) were estimated by immunostaining and image analysis in stroma and glandular epithelium. The level of apoptosis was evaluated by the TUNEL assay. Wilcoxon matched-pairs test was used for the statistical analysis of data.Results: The mean serum levels of E2, SHBG and P were higher in substitu

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/NH6611" target="_blank" >NH6611: Receptivita endometria ve vztahu k úspěšnosti přenosu kryokonzervovaných embryí.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Acta Medica Martiniana

ISSN

1335-8421

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

7

Strana od-do

22-28

Kód UT WoS článku

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EID výsledku v databázi Scopus

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