Vztah mezi MCP-1-2518 (A/G) a sarkoidózou u pacientů českého původu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001920" target="_blank" >RIV/61989592:15110/05:00001920 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

MCP-1-2518 (A/G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis

Popis výsledku v původním jazyce

Background and aim: Genetic factors controlling production of chemotactic cytokines are thought to be important for development of inflammatory response in pulmonary sarcoidosis. Monocyte chemoattractant protein (MCP)-1/CCL2, a chemokine recruiting mononuclear cells, has been shown to play important role in sarcoidosis. A single nucleotide polymorphism of the MCP-1 gene promotor (-2518*A/G) has been associated with increased production of MCP-1 protein. This study, therefore, aimed at exploring relationship between this polymorphism and pulmonary sarcoidosis including Löfgren's syndrome (LS). Methods: The MCP-1-2518 genotypes were determined using polymerase chain reaction with sequence specific primers in 130 patients with sarcoidosis and 359 healthycontrol subjects. ELISA was used to detect serum (n=91) and BALF (n=57) MCP-1 protein level. Results: While no significant difference in the allele distribution between patients with sarcoidosis and healthy controls was observed (P=0.17),

Název v anglickém jazyce

MCP-1-2518 (A/G) single nucleotide polymorphism in Czech patients with pulmonary sarcoidosis

Popis výsledku anglicky

Background and aim: Genetic factors controlling production of chemotactic cytokines are thought to be important for development of inflammatory response in pulmonary sarcoidosis. Monocyte chemoattractant protein (MCP)-1/CCL2, a chemokine recruiting mononuclear cells, has been shown to play important role in sarcoidosis. A single nucleotide polymorphism of the MCP-1 gene promotor (-2518*A/G) has been associated with increased production of MCP-1 protein. This study, therefore, aimed at exploring relationship between this polymorphism and pulmonary sarcoidosis including Löfgren's syndrome (LS). Methods: The MCP-1-2518 genotypes were determined using polymerase chain reaction with sequence specific primers in 130 patients with sarcoidosis and 359 healthycontrol subjects. ELISA was used to detect serum (n=91) and BALF (n=57) MCP-1 protein level. Results: While no significant difference in the allele distribution between patients with sarcoidosis and healthy controls was observed (P=0.17),

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA310%2F05%2F2614" target="_blank" >GA310/05/2614: Expresní profilování chemokinových ligandů a receptorů u pulmonární sarkoidózy</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Respirace

ISSN

1211-572X

e-ISSN

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Svazek periodika

2

Číslo periodika v rámci svazku

18

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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