p53 - prognostický faktor maligní transformace u Baretovho jícnu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F05%3A00001933" target="_blank" >RIV/61989592:15110/05:00001933 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

p53 - Prognostic factor of malignant transformation of barrett's esophagus.

Popis výsledku v původním jazyce

The most signi&#64257;cant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformationis determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indicationof "preventive" extirpation of the esophagus should be supported by other factors, for example by detection of p53mutation or expression.The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Departmentof Surgery, the p53 level and its correlation with histological &#64257;ndings evaluated in these patients.A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlationwas also con&#64257;rmed by detection of early carcinoma in patients with "preventive" extirpation of the esophagusdue to a high-grade dysplasia.Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may behelpf

Název v anglickém jazyce

p53 - Prognostic factor of malignant transformation of barrett's esophagus.

Popis výsledku anglicky

The most signi&#64257;cant precancerosis in the esophageal cancer is Barrett's esophagus. The risk of malignant transformationis determined primarily in accordance with the degree of dysplastic alterations of the mucosa. Indicationof "preventive" extirpation of the esophagus should be supported by other factors, for example by detection of p53mutation or expression.The study reports on the evaluation of a group of 20 patients with Barrett's esophagus treated at the 1st Departmentof Surgery, the p53 level and its correlation with histological &#64257;ndings evaluated in these patients.A good correlation was found between the grade of Barrett's esophagus dysplasia and high p53 positivity. This correlationwas also con&#64257;rmed by detection of early carcinoma in patients with "preventive" extirpation of the esophagusdue to a high-grade dysplasia.Preliminary results show that examination of p53 level in specimens taken from the esophageal mucosa may behelpf

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2005

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Svazek periodika

149

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

4

Strana od-do

141-144

Kód UT WoS článku

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EID výsledku v databázi Scopus

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