Mikrotubulární síť v signalizaci glukokortikoidního a aryl uhlovodíkového receptoru.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F06%3A00003511" target="_blank" >RIV/61989592:15110/06:00003511 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling

Popis výsledku v původním jazyce

Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. directand/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependenceof their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating c

Název v anglickém jazyce

Microtubules network in glucocortocoid receptor and aryl hydrocarbon receptor signaling

Popis výsledku anglicky

Glucocorticoid receptor (GR) and aryl hydrocarbon receptor (AhR) are two entirely different individuals, the former being a typical steroid receptor integrated in endogenous affairs, the latter being the first described xeno-receptor, so-called dioxin receptor. Interestingly, these two receptors share several common features: 1) involvement in essential cellular processes such as proliferation, differentiation, inflammatory response, and gene expression; 2) essential role in drug metabolism, i.e. directand/or indirect control of phase I, II, and III enzymes expression. 3) mechanism of their action in terms of ligand binding, nuclear import and export, and proteasome-mediated degradation, the last feature serving as negative feedback. 4) The dependenceof their activity on the status of microtubules network. Despite voluminous data published, the role of microtubules in GR signaling is still controversial. Crucial appears the distinction between proliferating versus non-proliferating c

Druh

C - Kapitola v odborné knize

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Focus on Cellular Signaling Research

ISBN

1-59454-619-3

Počet stran výsledku

161

Strana od-do

29-54

Počet stran knihy

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Název nakladatele

Nova Science Publisher, Inc.

Místo vydání

New York

Kód UT WoS kapitoly

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