SUBCHRONICKÁ STUDIE TOXICITY DIHYDROSANGUINARINU

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00003563" target="_blank" >RIV/61989592:15110/07:00003563 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A subchronic oral toxicity study of dihydrosanguinarine

Popis výsledku v původním jazyce

The quarternary benzo[c]phenanthridine (QBA) alkaloid, sanguinarine (SG) is known for a range of biological activities (antimicrobial, anti-inflamatory, etc.). Only recently has reduction of SG been designated as the first step in its metabolism and detoxification, yielding dihydrosanguinarine (DHSG) as a first metabolite. The toxicity of DHSG has never been studied which is rather surprising seeing that DHSG is identified as the toxic component involved in the Epidemic dropsy syndrome, caused by Argemone mexicana oil. This syndrome related to oxidative stress. The aim of our study was to gather reliable data on any subchronic toxicity and oxidative stress related to (DHSG) in oral study in rats. Rats were fed a diet containing 100 ppm and 500 ppm of DHSG for 90 days. The daily dose of DHSG for 100 ppm and 500 ppm groups, respectively, fell from 17 and 80,8 mg/kg b.w. at the beginning to 7.83 and 35,5 mg/kg b.w., at the end of the experiment, i.e. averaged doses over 90 days were 12,4

Název v anglickém jazyce

A subchronic oral toxicity study of dihydrosanguinarine

Popis výsledku anglicky

The quarternary benzo[c]phenanthridine (QBA) alkaloid, sanguinarine (SG) is known for a range of biological activities (antimicrobial, anti-inflamatory, etc.). Only recently has reduction of SG been designated as the first step in its metabolism and detoxification, yielding dihydrosanguinarine (DHSG) as a first metabolite. The toxicity of DHSG has never been studied which is rather surprising seeing that DHSG is identified as the toxic component involved in the Epidemic dropsy syndrome, caused by Argemone mexicana oil. This syndrome related to oxidative stress. The aim of our study was to gather reliable data on any subchronic toxicity and oxidative stress related to (DHSG) in oral study in rats. Rats were fed a diet containing 100 ppm and 500 ppm of DHSG for 90 days. The daily dose of DHSG for 100 ppm and 500 ppm groups, respectively, fell from 17 and 80,8 mg/kg b.w. at the beginning to 7.83 and 35,5 mg/kg b.w., at the end of the experiment, i.e. averaged doses over 90 days were 12,4

Druh

D - Stať ve sborníku

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA525%2F07%2F0871" target="_blank" >GA525/07/0871: Detoxifikace kvartérních isochinolinových alkaloidů in vitro a in vivo, biologická aktivita jejich metabolitů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

6th International Conference of PhD Students

ISBN

978-963-661-780-6

ISSN

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e-ISSN

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Počet stran výsledku

215

Strana od-do

191-193

Název nakladatele

University of Miskolc

Místo vydání

Miskolc, Hungary

Místo konání akce

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Datum konání akce

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Typ akce podle státní příslušnosti

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Kód UT WoS článku

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