EXPRESE P53, KI-67, BCL-2, C-ERB-2, ESTROGENOVÉHO, A PROGESTERONOVÉHO RECEPTORU U ENDOMETRIÁLNÍHO KARCINOMU

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00003980" target="_blank" >RIV/61989592:15110/07:00003980 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EXPRESSION OF P53, KI-67, BCL-2, C-ERB-2, ESTROGEN, AND PROGESTERONE RECEPTORS IN ENDOMETRIAL CANCER

Popis výsledku v původním jazyce

Objective: To assess the immunohistochemical expression of p53, bcl-2, c-erb-2, Ki-67, estrogen and progesterone receptors in endometrial cancer patients. Methods: We studied 103 cases of primary untreated endometrial carcinoma in which the p53, bcl-2, cerb- 2, Ki-67, estrogen and progesterone receptor antigens were investigated by an immunohistochemical method. We evaluated the correlations among the immunohistochemical staining assessed by histoscore, and the age, grading, depth of invasion, stage ofthe neoplasia and extrauterine disease. Results: Mean age was 67 years (range 35-90). All patients were submitted to total abdominal or modified radical hysterectomy plus bilateral salpingoophorectomy. Systematic pelvic lymphadenectomy was performed in 75 (72.5%) high-risk patients. p53, bcl-2, c-erb-2, Ki-67, estrogen and progesterone receptors were positive in 49 (48%), 81 (79%). 18 (17%), 99 (96%), 73 (70%) and 87 (84%) patients respectively. There was no clear association between imm

Název v anglickém jazyce

EXPRESSION OF P53, KI-67, BCL-2, C-ERB-2, ESTROGEN, AND PROGESTERONE RECEPTORS IN ENDOMETRIAL CANCER

Popis výsledku anglicky

Objective: To assess the immunohistochemical expression of p53, bcl-2, c-erb-2, Ki-67, estrogen and progesterone receptors in endometrial cancer patients. Methods: We studied 103 cases of primary untreated endometrial carcinoma in which the p53, bcl-2, cerb- 2, Ki-67, estrogen and progesterone receptor antigens were investigated by an immunohistochemical method. We evaluated the correlations among the immunohistochemical staining assessed by histoscore, and the age, grading, depth of invasion, stage ofthe neoplasia and extrauterine disease. Results: Mean age was 67 years (range 35-90). All patients were submitted to total abdominal or modified radical hysterectomy plus bilateral salpingoophorectomy. Systematic pelvic lymphadenectomy was performed in 75 (72.5%) high-risk patients. p53, bcl-2, c-erb-2, Ki-67, estrogen and progesterone receptors were positive in 49 (48%), 81 (79%). 18 (17%), 99 (96%), 73 (70%) and 87 (84%) patients respectively. There was no clear association between imm

Druh

A - Audiovizuální tvorba

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

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Projekt

<a href="/cs/project/NR9098" target="_blank" >NR9098: Význam imunohistochemických markerů pro prognózu karcinomu endometria</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

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Název nakladatele resp. objednatele

European society of gynecological oncology

Verze

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Identifikační číslo nosiče

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