Vysazení mykofenolát mofetilu z imunosupresivního protokolu založeném na trojkombinaci s tacrolimem 2 měsíce po transplantaci ledvin: srovnávací randomizovaná multicentrická studie.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004033" target="_blank" >RIV/61989592:15110/07:00004033 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study

Popis výsledku v původním jazyce

Previous clinical data suggested that with a tacrolimus-based regimen adjunctive immunosuppressives may be withdrawn after an initial treatment period. This study investigated the early discontinuation of mycophenolate mofetil (MMF) from a standard triple regimen. Patients were randomized either to receive a continued tacrolimus /MMF/ steroids triple regimen (control group) or to reduce and then stop the MMF dose (MMF stop group). Both groups received identical daily tacrolimus and corticosteroid doses.The initial MMF dose was l g/day in both arms, but in the MMF stop group the dose was reduced to 0,5 g/day from week 7 to 12 and then stopped. The intent-to-treat population consisted of 74 (control) and 78 (MMF stop) patients. MMF was tapered off as planned in 82.9% of the patients in the MMF stop arm. The 6-month incidence of biopsy-proven acute rejection was similar in both arms (21.6% control, 16.7% MMMF stop). Graft loss occurred in 5.4% (control) and 3.8% (MMF stop) of the patient

Název v anglickém jazyce

Discontinuation of mycophenolate mofetil from a tacrolimus-based triple 2 months after renal transplantation : a comparative randomized multicentre study

Popis výsledku anglicky

Previous clinical data suggested that with a tacrolimus-based regimen adjunctive immunosuppressives may be withdrawn after an initial treatment period. This study investigated the early discontinuation of mycophenolate mofetil (MMF) from a standard triple regimen. Patients were randomized either to receive a continued tacrolimus /MMF/ steroids triple regimen (control group) or to reduce and then stop the MMF dose (MMF stop group). Both groups received identical daily tacrolimus and corticosteroid doses.The initial MMF dose was l g/day in both arms, but in the MMF stop group the dose was reduced to 0,5 g/day from week 7 to 12 and then stopped. The intent-to-treat population consisted of 74 (control) and 78 (MMF stop) patients. MMF was tapered off as planned in 82.9% of the patients in the MMF stop arm. The 6-month incidence of biopsy-proven acute rejection was similar in both arms (21.6% control, 16.7% MMMF stop). Graft loss occurred in 5.4% (control) and 3.8% (MMF stop) of the patient

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Transplant International

ISSN

0934-0874

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

230-237

Kód UT WoS článku

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EID výsledku v databázi Scopus

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