Komplement: přítel či nepřítel systémového lupus erythematosus?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004301" target="_blank" >RIV/61989592:15110/07:00004301 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Complement: a friend or foe in systemic lupus erythematosus?

Popis výsledku v původním jazyce

Systemic lupus erythematosus (SLE) is an autoimmune disorder which affects multiple organ systems and whose etiology still remains unknown. Nonetheless, many aspects of cellular and molecular interaction leading to the loss of self-tolerance have been clarified. The complement system plays a major yet ambivalent role in pathogenesis of systemic diseases especially SLE. On the one hand activation of the complement system leads to organ damage; on the other hand the complement system partakes in preserving the solubility of immune complexes and their transport to phagocytes of the reticulum-endothelial system and on the clearance of apoptotic cells from circulation. Both hereditary and acquired complement deficiencies are linked to various diseases. SLEcan be considered as a prototype of autoimmune disease, and can be used to demonstrate a variety of examples of complement dysfunction. The dysfunctions of the complement system aren?t only epiphenomenon found in SLE; they also play a fun

Název v anglickém jazyce

Complement: a friend or foe in systemic lupus erythematosus?

Popis výsledku anglicky

Systemic lupus erythematosus (SLE) is an autoimmune disorder which affects multiple organ systems and whose etiology still remains unknown. Nonetheless, many aspects of cellular and molecular interaction leading to the loss of self-tolerance have been clarified. The complement system plays a major yet ambivalent role in pathogenesis of systemic diseases especially SLE. On the one hand activation of the complement system leads to organ damage; on the other hand the complement system partakes in preserving the solubility of immune complexes and their transport to phagocytes of the reticulum-endothelial system and on the clearance of apoptotic cells from circulation. Both hereditary and acquired complement deficiencies are linked to various diseases. SLEcan be considered as a prototype of autoimmune disease, and can be used to demonstrate a variety of examples of complement dysfunction. The dysfunctions of the complement system aren?t only epiphenomenon found in SLE; they also play a fun

Druh

C - Kapitola v odborné knize

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Systemic Lupus Erythematosus Research Developments

ISBN

978-1-60021-859-0

Počet stran výsledku

235

Strana od-do

135-154

Počet stran knihy

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Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

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Kód UT WoS kapitoly

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