Vysoce dávkovaná chemoterapie a autologní transplantace u pacientů s rizikovým Difuzním velkobuněčným B lymfomem v 1. remisi

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004380" target="_blank" >RIV/61989592:15110/07:00004380 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

High-dose therapy and autologous transplantation in poor prognosis patients with diffuse large B-cell lymphoma in first remission

Popis výsledku v původním jazyce

Introduction: Improved survival has been observed in poor-risk diffuse large B-cell lymphoma (DLBCL) patients when treated with high-dose chemotherapy followed autologous transplantation (ASCT). Materials and Methods: We evaluated the results of HDT andASCT in 55 patients treated between May 1999 and July 2006 with confimed DLBCL. Results: 36 patients (65%) had a partial response (PR) and 19 patiennts (35%) reached a complete remission (CR) after induction treatment with (44%) or without (56%) concomitant rituximab ? immunotherapy. After HDT and ASCT 69% patients fulfilled the criteria of CR, 22% patients ahd and unconfirmedCR (Cru), 7% patients were still only in PR and 1 patient (2%) relapsed. The 5-year event-free survival (EFS) of the 55 transplanted patients was 76% and the 5-year overall survival (OS) was 85%. EFS and OS rates differed significantly only between patients younger than 40 years and older groups (p=0.022 and p=0.046, respectively). Conclusion: These results shows t

Název v anglickém jazyce

High-dose therapy and autologous transplantation in poor prognosis patients with diffuse large B-cell lymphoma in first remission

Popis výsledku anglicky

Introduction: Improved survival has been observed in poor-risk diffuse large B-cell lymphoma (DLBCL) patients when treated with high-dose chemotherapy followed autologous transplantation (ASCT). Materials and Methods: We evaluated the results of HDT andASCT in 55 patients treated between May 1999 and July 2006 with confimed DLBCL. Results: 36 patients (65%) had a partial response (PR) and 19 patiennts (35%) reached a complete remission (CR) after induction treatment with (44%) or without (56%) concomitant rituximab ? immunotherapy. After HDT and ASCT 69% patients fulfilled the criteria of CR, 22% patients ahd and unconfirmedCR (Cru), 7% patients were still only in PR and 1 patient (2%) relapsed. The 5-year event-free survival (EFS) of the 55 transplanted patients was 76% and the 5-year overall survival (OS) was 85%. EFS and OS rates differed significantly only between patients younger than 40 years and older groups (p=0.022 and p=0.046, respectively). Conclusion: These results shows t

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Blood reviews

ISSN

0268-960X

e-ISSN

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Svazek periodika

21

Číslo periodika v rámci svazku

S1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

93

Strana od-do

93

Kód UT WoS článku

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EID výsledku v databázi Scopus

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