Dicentrické chromosomy u dětských akutních lymfoblastických leukemií (ALL)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F07%3A00004451" target="_blank" >RIV/61989592:15110/07:00004451 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Dicentric chromosomes in childhood acute lymphoblastic leukemia (ALL)

Popis výsledku v původním jazyce

The identification of recurring chromosomal translocations in pediatric acute lymphoblastic leukemia (ALL) can provide clues to the cellular events with biological and clinical significance. Chromosomal translocations resulting in dicentric and isodicentric chromosomes are less common chromosomal abnormalities in leukemias nevertheless they are also detected in childhood ALL with different impact on prognosis. Dicentric chromosome is a derivative chromosome with two centromeres of different origin, while isodicentric chromosome arises from translocation of two homologous chromosomes. The aim of our study was to precisely characterize dicentric and/or isodicentric chromosomes by using cytogenetic and molecular cytogenetic methods and to evaluate their clinical significance. From 1996 to 2006, 145 children with a newly diagnosed ALL were analyzed by conventional cytogenetic and molecular cytogenetic techniques (FISH and/or mFISH and/or mBAND FISH and/or CGH). Dicentric and/or isodicentri

Název v anglickém jazyce

Dicentric chromosomes in childhood acute lymphoblastic leukemia (ALL)

Popis výsledku anglicky

The identification of recurring chromosomal translocations in pediatric acute lymphoblastic leukemia (ALL) can provide clues to the cellular events with biological and clinical significance. Chromosomal translocations resulting in dicentric and isodicentric chromosomes are less common chromosomal abnormalities in leukemias nevertheless they are also detected in childhood ALL with different impact on prognosis. Dicentric chromosome is a derivative chromosome with two centromeres of different origin, while isodicentric chromosome arises from translocation of two homologous chromosomes. The aim of our study was to precisely characterize dicentric and/or isodicentric chromosomes by using cytogenetic and molecular cytogenetic methods and to evaluate their clinical significance. From 1996 to 2006, 145 children with a newly diagnosed ALL were analyzed by conventional cytogenetic and molecular cytogenetic techniques (FISH and/or mFISH and/or mBAND FISH and/or CGH). Dicentric and/or isodicentri

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2007

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chromosome Research

ISSN

0967-3849

e-ISSN

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Svazek periodika

15

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

185

Strana od-do

185

Kód UT WoS článku

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EID výsledku v databázi Scopus

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