Chromosomové změny 2p u chronické lymfocytární leukemie

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006209" target="_blank" >RIV/61989592:15110/08:00006209 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Gains of chromosome 2p in chronic lymphocytic leukemia

Popis výsledku v původním jazyce

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The progress in molecular genetic characterization of CLL confirmed the prognostic role of IgVH mutational status, expression of CD38, as well as chromosomal abnormalities defined by molecular cytogenetic methods. However, besides chromosomal changes with known prognostic impact, such as deletions of 6q, 11q (ATM), 13q, 17p (p53) detected routinely, the other additional abnormalities can be found. It is presently not clear whether other aberrations that are not detected by the standard FISH panel have any impact on prognosis and disease progression. Therefore, we performed clinical and laboratory analysis of 7 CLL patients (males) with detected gains of chromosome 2p. The aim of thegenetic study was supported by the fact, that gains of genetic material can lead to oncogenic activation of protooncogenes located within the gained regions. Since 2p23~p11 harbors many protooncogenes already known to be involved in human

Název v anglickém jazyce

Gains of chromosome 2p in chronic lymphocytic leukemia

Popis výsledku anglicky

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. The progress in molecular genetic characterization of CLL confirmed the prognostic role of IgVH mutational status, expression of CD38, as well as chromosomal abnormalities defined by molecular cytogenetic methods. However, besides chromosomal changes with known prognostic impact, such as deletions of 6q, 11q (ATM), 13q, 17p (p53) detected routinely, the other additional abnormalities can be found. It is presently not clear whether other aberrations that are not detected by the standard FISH panel have any impact on prognosis and disease progression. Therefore, we performed clinical and laboratory analysis of 7 CLL patients (males) with detected gains of chromosome 2p. The aim of thegenetic study was supported by the fact, that gains of genetic material can lead to oncogenic activation of protooncogenes located within the gained regions. Since 2p23~p11 harbors many protooncogenes already known to be involved in human

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

—

Projekt

<a href="/cs/project/NR9484" target="_blank" >NR9484: Určení nových genetických změn v nádorovém genomu nemocných s chronickou B lymfocytární leukémií (B-CLL) metodou array komparativní genomové hybridizace</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Human Genetics

ISSN

1018-4813

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

1

Strana od-do

—

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—