Zjištění MMP-2 a MMP-9 u standardně probíhající gravidity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00006295" target="_blank" >RIV/61989592:15110/08:00006295 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Detection of MMP-2 and MMP-9 in normal uncomplicated pregnancy

Popis výsledku v původním jazyce

Backround: The invasion of extravillous trophoblast cells into the maternal endometrium is one of the key events in human placentation. The ability of these cells to infiltrate the uterine wall and to anchor the placenta to it as well as their ability toinfiltrate and adjust utero-placental vessels to pregnancy depends, among other things, on their ability to secrete enzymes that degrade the extracellular matrix. Most of these enzymes belong to the family of matrix metalloproteinases. Matrix metalloproteinases (MMPs) belong to secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. This assay can be used in detecting MMP activity in biological samples using a EDANS/DABCYL fluorescence resonance energytransfer (FRET) peptide. Aim of the study: To evaluate MMP-2 and MMP-9 in healthy pregnant women Material and methods: We ascertained group of 40 women with uncomplicated pregnancy. The levels of MMP were be measured in plasma samples. Th

Název v anglickém jazyce

Detection of MMP-2 and MMP-9 in normal uncomplicated pregnancy

Popis výsledku anglicky

Backround: The invasion of extravillous trophoblast cells into the maternal endometrium is one of the key events in human placentation. The ability of these cells to infiltrate the uterine wall and to anchor the placenta to it as well as their ability toinfiltrate and adjust utero-placental vessels to pregnancy depends, among other things, on their ability to secrete enzymes that degrade the extracellular matrix. Most of these enzymes belong to the family of matrix metalloproteinases. Matrix metalloproteinases (MMPs) belong to secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components. This assay can be used in detecting MMP activity in biological samples using a EDANS/DABCYL fluorescence resonance energytransfer (FRET) peptide. Aim of the study: To evaluate MMP-2 and MMP-9 in healthy pregnant women Material and methods: We ascertained group of 40 women with uncomplicated pregnancy. The levels of MMP were be measured in plasma samples. Th

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9282" target="_blank" >NR9282: Význam markerů aktivace endotelu v predikci rozvoje preeklampsie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pathophysiology of Haemostasis and Thrombosis

ISSN

1424-8832

e-ISSN

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Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

1

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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