MMP-26 a TIMP-4 v lidském endometriu

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007346" target="_blank" >RIV/61989592:15110/08:00007346 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

MMP-26 and TIMP-4 in the human endometrium

Popis výsledku v původním jazyce

The aim of this work was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in the human endometrium. Both these enzymes may be implicated in the implantation process. Trophoblast tissue from human, as well as mice embryo produces pro-MMP-9. Active MMP-9 is a proteolytic enzyme with a broad substrate specificity. MMP-26 is an affective activator of pro-MMP-9, and TIMP-4 is a strong inhibitor of MMP-26. We have shown that the endometrial expression of MMP-26 and TIMP-4 genes is maximal in mid-cycle. The expression pattern of both genes suggests their up-regulation by estrogen, and down-regulation by progesterone. This is supported by our findings of estrogen response elements upstream the coding sequencesof both genes. Our findings suggest that TIMP-4 is produced in the stroma only, secreted by stromal cells, taken up by epithelial cells, accumulated in apical granules, and finally secreted to the uterine fluid. Results of MMP-26 and TIM

Název v anglickém jazyce

MMP-26 and TIMP-4 in the human endometrium

Popis výsledku anglicky

The aim of this work was to study matrix metalloproteinase-26 (MMP-26) and tissue inhibitor of metalloproteinases-4 (TIMP-4) in the human endometrium. Both these enzymes may be implicated in the implantation process. Trophoblast tissue from human, as well as mice embryo produces pro-MMP-9. Active MMP-9 is a proteolytic enzyme with a broad substrate specificity. MMP-26 is an affective activator of pro-MMP-9, and TIMP-4 is a strong inhibitor of MMP-26. We have shown that the endometrial expression of MMP-26 and TIMP-4 genes is maximal in mid-cycle. The expression pattern of both genes suggests their up-regulation by estrogen, and down-regulation by progesterone. This is supported by our findings of estrogen response elements upstream the coding sequencesof both genes. Our findings suggest that TIMP-4 is produced in the stroma only, secreted by stromal cells, taken up by epithelial cells, accumulated in apical granules, and finally secreted to the uterine fluid. Results of MMP-26 and TIM

Druh

B - Odborná kniha

CEP obor

FK - Gynekologie a porodnictví

OECD FORD obor

—

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

978-3-639-07448-2

Počet stran knihy

100

Název nakladatele

Verlag Dr. Müller, Saarbrücken, Germany

Místo vydání

Lund, Švédsko

Kód UT WoS knihy

—