In vivo studie vlivu antivirálního acyklického nukleotidfosfonátu (R)-9-[2-(fosfonomethoxy)propyl]adenin (PMPA, tenofovir) a jeho prodrug tenofovir disoproxil fumarátu na mikrosomální cytochrom P450 u potkana.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00007584" target="_blank" >RIV/61989592:15110/08:00007584 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378041:_____/08:00315836 RIV/61388963:_____/08:00315836

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

In Vivo Study of the Effect of Antiviral Acyclic Nucleotide Phosphonate /R)-9-[2-(phosphonomethoxy)propyl}adenine(PMPA, tenofovir) and Its Prodrug Tenofovir Disoproxil Fumarate on rat microsomal Cytochrome P450

Popis výsledku v původním jazyce

The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)?9?[2? (phosphonomethoxy)propyl]adenine) and tenofovir disoproxil at a daily dose 25 mg.kg-1.The content of liver microsomal protein however did not change. The decrease of the CYP content was accompanied by concomitant increase of the amount of inactive CYP form, cytochrome P420. This effect was confirmed by a parallel study of the activities of selected CYP forms, CYP2E1 (p-nitrophenol hydroxylation) and CYP1A2 (7-ethoxyresorufin deethylation). The activity (expressed relatively to the protein content) of both CYP forms decreased significantly following the decrease of the total CYP. On the other hand, the CYP2E1 activity expressed relatively to the (decreasing) total CYP content remained unchanged. CYP1A2 activity however decreased as well when calculated relatively to the total native CYP content indicating lower stability

Název v anglickém jazyce

In Vivo Study of the Effect of Antiviral Acyclic Nucleotide Phosphonate /R)-9-[2-(phosphonomethoxy)propyl}adenine(PMPA, tenofovir) and Its Prodrug Tenofovir Disoproxil Fumarate on rat microsomal Cytochrome P450

Popis výsledku anglicky

The total content of rat liver microsomal cytochrome P450 (CYP) significantly decreased after repeated i.p. administration of the antiviral agent tenofovir ((R)?9?[2? (phosphonomethoxy)propyl]adenine) and tenofovir disoproxil at a daily dose 25 mg.kg-1.The content of liver microsomal protein however did not change. The decrease of the CYP content was accompanied by concomitant increase of the amount of inactive CYP form, cytochrome P420. This effect was confirmed by a parallel study of the activities of selected CYP forms, CYP2E1 (p-nitrophenol hydroxylation) and CYP1A2 (7-ethoxyresorufin deethylation). The activity (expressed relatively to the protein content) of both CYP forms decreased significantly following the decrease of the total CYP. On the other hand, the CYP2E1 activity expressed relatively to the (decreasing) total CYP content remained unchanged. CYP1A2 activity however decreased as well when calculated relatively to the total native CYP content indicating lower stability

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/1M0508" target="_blank" >1M0508: Nová antivirotika a antineoplastika</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Physiological Research

ISSN

0862-8408

e-ISSN

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Svazek periodika

57

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

7

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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