Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A00009735" target="_blank" >RIV/61989592:15110/08:00009735 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/08:#0000082

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients

Popis výsledku v původním jazyce

Thrombin generation test (TGT) was developed several years ago to mimic physiological coagulation. It can be used in many applications including assessment of thrombophilia state. We used this test for observation of influence of cell-derived microparticles, platelet (PMP) and endothelias (EMP), on thrombin generation in patients with good defined thrombophilia state such as Factor V Leiden (FVL) mutation. We evaluated thrombin generation parametres in samples with and without microparticles and determined their influence on clinical course of thrombophilia state in group of 25 carriers of heterozygous form of FVL. We found significant correlation between amount of generated thrombin and microparticles level. Patients with higher thrombin generation were more often affected by thrombotic complication.

Název v anglickém jazyce

Influence of Circulating Cell-derived Microparticles on Thrombin Generation in Thrombophilia Patients

Popis výsledku anglicky

Thrombin generation test (TGT) was developed several years ago to mimic physiological coagulation. It can be used in many applications including assessment of thrombophilia state. We used this test for observation of influence of cell-derived microparticles, platelet (PMP) and endothelias (EMP), on thrombin generation in patients with good defined thrombophilia state such as Factor V Leiden (FVL) mutation. We evaluated thrombin generation parametres in samples with and without microparticles and determined their influence on clinical course of thrombophilia state in group of 25 carriers of heterozygous form of FVL. We found significant correlation between amount of generated thrombin and microparticles level. Patients with higher thrombin generation were more often affected by thrombotic complication.

Druh

D - Stať ve sborníku

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

<a href="/cs/project/NR9282" target="_blank" >NR9282: Význam markerů aktivace endotelu v predikci rozvoje preeklampsie</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 20th International Congress on Thrombosis

ISBN

978-88-7587-423-0

ISSN

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e-ISSN

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Počet stran výsledku

182

Strana od-do

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Název nakladatele

Liapis, CD; Antonios, HN

Místo vydání

Ahtens, Greece

Místo konání akce

20th International Congress on Thrombosis

Datum konání akce

25. 6. 2008

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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