Detection of clopidogrel resistence in patients undergoing elective percutaneous coronary intevention

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F08%3A10224408" target="_blank" >RIV/61989592:15110/08:10224408 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Detection of clopidogrel resistence in patients undergoing elective percutaneous coronary intevention

Popis výsledku v původním jazyce

Clopidogrel is a potent drug for prevention of adverse effects during and after percutaneous coronary intervention (PCI). Failure of antiplatelet therapy can have severe consequences; demanding for a reliable assay to quantify the effectiveness of clopidogrel treatment. In the traditional test to control this type of treatment, ADP has been used as the activator, which is not specific only to the P2Y12 receptor. We compare the light transmitting aggregometry (APACT 4004, Helena Laboratories, Austria) and the impedance aggregometry (Multiplate analyzer, Dynabyte Medical, Munich, Germany). Platelet aggregation was measured after stimulation with ADP and prostaglandin E1 by aggregometry within 2 - 5 days from the outset of this treatment with clopidogrel.

Název v anglickém jazyce

Detection of clopidogrel resistence in patients undergoing elective percutaneous coronary intevention

Popis výsledku anglicky

Clopidogrel is a potent drug for prevention of adverse effects during and after percutaneous coronary intervention (PCI). Failure of antiplatelet therapy can have severe consequences; demanding for a reliable assay to quantify the effectiveness of clopidogrel treatment. In the traditional test to control this type of treatment, ADP has been used as the activator, which is not specific only to the P2Y12 receptor. We compare the light transmitting aggregometry (APACT 4004, Helena Laboratories, Austria) and the impedance aggregometry (Multiplate analyzer, Dynabyte Medical, Munich, Germany). Platelet aggregation was measured after stimulation with ADP and prostaglandin E1 by aggregometry within 2 - 5 days from the outset of this treatment with clopidogrel.

Druh

O - Ostatní výsledky

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů