Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A00009655" target="_blank" >RIV/61989592:15110/09:00009655 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

Popis výsledku v původním jazyce

The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P= 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.

Název v anglickém jazyce

Association of MCP-1 -2518 A/G single nucleotide polymorphism with the serum level of CRP in Slovak patients with ischemic heart disease, angina pectoris and hypertension

Popis výsledku anglicky

The aim of our work was to found if MCP-1 -2518 (A/G) single nucleotide polymorfism (SNP) influences anyway the serum concentrations of hsCRP (high sensitive CRP) both in patiens suffering from ischemic heart disease (IHD), myocardial infarction (MI), angina pectoris (AP) and hypertension (HT) and in control group of healthy subjects. First, we estimated the serum levels of hsCRP. We found that patients with AP had significantly higher serum level of hsCRP than both control group of healthy subjects (P= 0.043) and IHD patients without AP (P = 0.026). The presence of the mutant G allele statistically significantly correlated with the higher serum levels of hsCRP in patients with IHD (P = 0.016), AP (P = 0.004) and HT (P = 0.013). Higher correlations were found in men (AP: P = 0.019; HT: P = 0.047). In all cases the highest levels of hsCRP were found both in patients and healthy controls with homozygous GG genotype.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

—

Projekt

<a href="/cs/project/ME%20856" target="_blank" >ME 856: Polymorfismus genů pro chemotaktické cytokininy a jejich receptory u slovanských pacientů s infarktem myokardu</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Mediators of Inflammation

ISSN

0962-9351

e-ISSN

—

Svazek periodika

2009

Číslo periodika v rámci svazku

390951

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

—

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—