Expression of p53, p21 and p16 does Nor Correlate with Response to Preoperative Chemoradiation in Gastric Carcinoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A10223889" target="_blank" >RIV/61989592:15110/09:10223889 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Expression of p53, p21 and p16 does Nor Correlate with Response to Preoperative Chemoradiation in Gastric Carcinoma

Popis výsledku v původním jazyce

A retrospective evaluation was oerformed to determine whether the intensity of p53, p21 or p16 expression predicts response to preoperative chemoradiotherapy in locally advanced gastric carcinoma. Methodology: Thirty-six patients (cT2-4 or N+) were studied. Preoperative treatment consisted of 30-45Gy of radiation with continuous 5-fluorouracil and weekly cisplatin. Expression of p53, p21 and p16 in pretreatment biopsies was assessed by immunohistochemistry. Level of expression was determined from the intensity and extent of staining. Tumor downstaging was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination.

Název v anglickém jazyce

Expression of p53, p21 and p16 does Nor Correlate with Response to Preoperative Chemoradiation in Gastric Carcinoma

Popis výsledku anglicky

A retrospective evaluation was oerformed to determine whether the intensity of p53, p21 or p16 expression predicts response to preoperative chemoradiotherapy in locally advanced gastric carcinoma. Methodology: Thirty-six patients (cT2-4 or N+) were studied. Preoperative treatment consisted of 30-45Gy of radiation with continuous 5-fluorouracil and weekly cisplatin. Expression of p53, p21 and p16 in pretreatment biopsies was assessed by immunohistochemistry. Level of expression was determined from the intensity and extent of staining. Tumor downstaging was defined as a reduction of at least one T-stage level and/or finding of intense tumor regression in histopathologic examination.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

H.G.E. Update Medicial Publishing S.A. Athens-Stuttgart

ISSN

0172-6390

e-ISSN

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Svazek periodika

2009

Číslo periodika v rámci svazku

56

Stát vydavatele periodika

GR - Řecká republika

Počet stran výsledku

6

Strana od-do

1213-1218

Kód UT WoS článku

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EID výsledku v databázi Scopus

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