Cardioprotective effect of 2',3, 4'- trihydroxychalcone in preclinical experiment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F09%3A10224137" target="_blank" >RIV/61989592:15110/09:10224137 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cardioprotective effect of 2',3, 4'- trihydroxychalcone in preclinical experiment

Popis výsledku v původním jazyce

2',3,4'- trihydroxychalcone is a newly synthesized substance with antioxidant properties. The aim of this pilot study was to monitor its effect during heart perfusion in the laboratory rat. The study included two groups of animals of the same number (n=10). The 1st group was pretreated with chalcone in a dose of 10 mg/kg p.o. during 15 days. The 2nd group was a placebo one. After i.p. administration of a heparin injection of 500 IU dose, the hearts were excised and perfused (a modified Langendorf's method). Working schedule: stabilization/ischaemia/reperfusion proceed at intervals of 20/30/60 min. Monitored parameters in the isolated heart: left ventricle pressure (LVP), end-diastolic pressure (LVEDP), contractility (+dP/dt max). The treated hearts showed improved postischemie recovery, reaching LVP values of 101+-4% at the end of reperfusion,the placebo ones only 42+-6%. In the placebo hearts LVEDP increased from 10.0+-0,5 mm Hg to 32+- 5 mm Hg after, in treated animals only about 10.

Název v anglickém jazyce

Cardioprotective effect of 2',3, 4'- trihydroxychalcone in preclinical experiment

Popis výsledku anglicky

2',3,4'- trihydroxychalcone is a newly synthesized substance with antioxidant properties. The aim of this pilot study was to monitor its effect during heart perfusion in the laboratory rat. The study included two groups of animals of the same number (n=10). The 1st group was pretreated with chalcone in a dose of 10 mg/kg p.o. during 15 days. The 2nd group was a placebo one. After i.p. administration of a heparin injection of 500 IU dose, the hearts were excised and perfused (a modified Langendorf's method). Working schedule: stabilization/ischaemia/reperfusion proceed at intervals of 20/30/60 min. Monitored parameters in the isolated heart: left ventricle pressure (LVP), end-diastolic pressure (LVEDP), contractility (+dP/dt max). The treated hearts showed improved postischemie recovery, reaching LVP values of 101+-4% at the end of reperfusion,the placebo ones only 42+-6%. In the placebo hearts LVEDP increased from 10.0+-0,5 mm Hg to 32+- 5 mm Hg after, in treated animals only about 10.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Česká a slovenská farmacie

ISSN

1210-7816

e-ISSN

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Svazek periodika

58

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

5

Strana od-do

150-154

Kód UT WoS článku

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EID výsledku v databázi Scopus

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