Development of Löffler endocarditis in FIP1L1-PDGFRalpha positive hypereosinophilic syndrome despite continuous imatinib mesylate treatment and persistent complete remission

Kód výsledku v IS VaVaI

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Nalezeny alternativní kódy

RIV/61989592:15120/10:10224000

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of Löffler endocarditis in FIP1L1-PDGFRalpha positive hypereosinophilic syndrome despite continuous imatinib mesylate treatment and persistent complete remission

Popis výsledku v původním jazyce

We present a case of 32-year-old male with FIP1L1/PDGFRalpha positive hypereosinophilic syndrome, in whom complete clinical, hematological and molecular remission was achieved and sustained on 100 mg imatinib mesylate daily. The markedly increased thickness of left ventricular apical myocardium at the time of diagnosis diminished very quickly after imatinib and warfarin treatment and there was no detectable intramural thrombus on repeated echocardiographic checkups. After 28 months of imatinib therapy asymptomatic endocardial fibrosis and left ventricular apical thrombus developed, consistent with the diagnosis of Löffler endocarditis, confirmed by cardiac magnetic resonance. Restoration of warfarin therapy lead to gradual regression of the apical thrombus while the systolic and diastolic functions of the left ventricle remain normal. To our knowledge, no similar case of progression of Löffler endocarditis during persistent complete remission of hypereosinophilic syndrome was described

Název v anglickém jazyce

Development of Löffler endocarditis in FIP1L1-PDGFRalpha positive hypereosinophilic syndrome despite continuous imatinib mesylate treatment and persistent complete remission

Popis výsledku anglicky

We present a case of 32-year-old male with FIP1L1/PDGFRalpha positive hypereosinophilic syndrome, in whom complete clinical, hematological and molecular remission was achieved and sustained on 100 mg imatinib mesylate daily. The markedly increased thickness of left ventricular apical myocardium at the time of diagnosis diminished very quickly after imatinib and warfarin treatment and there was no detectable intramural thrombus on repeated echocardiographic checkups. After 28 months of imatinib therapy asymptomatic endocardial fibrosis and left ventricular apical thrombus developed, consistent with the diagnosis of Löffler endocarditis, confirmed by cardiac magnetic resonance. Restoration of warfarin therapy lead to gradual regression of the apical thrombus while the systolic and diastolic functions of the left ventricle remain normal. To our knowledge, no similar case of progression of Löffler endocarditis during persistent complete remission of hypereosinophilic syndrome was described

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FA - Kardiovaskulární nemoci včetně kardiochirurgie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

American Journal of Hematology

ISSN

1096-8652

e-ISSN

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Svazek periodika

85

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

296-299

Kód UT WoS článku

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EID výsledku v databázi Scopus

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