Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10223141" target="_blank" >RIV/61989592:15110/11:10223141 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/11:00370938 RIV/61989592:15310/11:10223141

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

Popis výsledku v původním jazyce

Flavonolignans, silybin and its derivatives and isosilybin were studied using ex situ C Vand SWV. The two oxidation steps were described for flavonolignans at potentials Ep1 +0.5 V and Ep2 +0.85 V. Oxidation peak at Ep3 +0.35 V was observed only for 2,3-dehydrosilybin. Results confirmed that 2,3-dehydrosilybin is a relatively strong antioxidant, which is strictly associated with oxidation at Ep3. Antioxidant parameters of flavonolignans can be affected by transition metal complexation via hydroxyl groups. Silybin and 2,3-dehydrosilybin are able to chelate transition metals, especially Cu2+. The electrochemical investigation of DNA interactions and damage caused in the presence of silybin/Cu complex and hydrogen peroxide is described. We present evidence that flavonolignans are involved not only in antioxidant abilities but also in the prooxidation effects under in vitro conditions.

Název v anglickém jazyce

Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

Popis výsledku anglicky

Flavonolignans, silybin and its derivatives and isosilybin were studied using ex situ C Vand SWV. The two oxidation steps were described for flavonolignans at potentials Ep1 +0.5 V and Ep2 +0.85 V. Oxidation peak at Ep3 +0.35 V was observed only for 2,3-dehydrosilybin. Results confirmed that 2,3-dehydrosilybin is a relatively strong antioxidant, which is strictly associated with oxidation at Ep3. Antioxidant parameters of flavonolignans can be affected by transition metal complexation via hydroxyl groups. Silybin and 2,3-dehydrosilybin are able to chelate transition metals, especially Cu2+. The electrochemical investigation of DNA interactions and damage caused in the presence of silybin/Cu complex and hydrogen peroxide is described. We present evidence that flavonolignans are involved not only in antioxidant abilities but also in the prooxidation effects under in vitro conditions.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Bioelectrochemistry

ISSN

1567-5394

e-ISSN

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Svazek periodika

82

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

117-124

Kód UT WoS článku

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EID výsledku v databázi Scopus

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