Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10224747" target="_blank" >RIV/61989592:15110/11:10224747 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia

Popis výsledku v původním jazyce

Whereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated CR1 expression on blood cells, the levels of circulating immune complexes (CIC) containing ligands of CR1, C1qcomplement protein and fragments of C3 complement protein (C1q-CIC, C3d-CIC), and CR1 C5507G functional polymorphism in schizophrenia patients and controls. We found an increased C1q-CIC level and CR1 expression on blood cells, elevated number of CR1 positive erythrocytes and reduced number of CR1 positive lymphocytes and monocytes in patients compared to controls. No difference in the levels of C3d-CIC between groups was observed. Our results indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Our study for the first time indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Further studies in other ethnic groups are needed to replicate these findings

Název v anglickém jazyce

Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia

Popis výsledku anglicky

Whereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated CR1 expression on blood cells, the levels of circulating immune complexes (CIC) containing ligands of CR1, C1qcomplement protein and fragments of C3 complement protein (C1q-CIC, C3d-CIC), and CR1 C5507G functional polymorphism in schizophrenia patients and controls. We found an increased C1q-CIC level and CR1 expression on blood cells, elevated number of CR1 positive erythrocytes and reduced number of CR1 positive lymphocytes and monocytes in patients compared to controls. No difference in the levels of C3d-CIC between groups was observed. Our results indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Our study for the first time indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Further studies in other ethnic groups are needed to replicate these findings

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/ED0030%2F01%2F01" target="_blank" >ED0030/01/01: Biomedicína pro regionální rozvoj a lidské zdroje</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BMC Clinical Pathology

ISSN

1472-6890

e-ISSN

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Svazek periodika

11

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

1-7

Kód UT WoS článku

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EID výsledku v databázi Scopus

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