Genetic determinant of prostate cancer: A review

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F11%3A10225034" target="_blank" >RIV/61989592:15110/11:10225034 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Genetic determinant of prostate cancer: A review

Popis výsledku v původním jazyce

Background. In prostate cancer, early detection and appropriate treatment remain key approaches. Genetic studies have revealed gene abnormalities which may be specifically associated with the risk of prostate cancer: changes in genes for the androgen receptor, RNAseL, ELAC2, MSR1, BRCA 1 and 2, HPCX, KLF6, HPC20 and fusion genes, e.g. TMPRSS2-ERG). Despite differing research results from molecular biological studies, these techniques can assist in earlier diagnosis enabling timely initiation of treatment. Methods. MEDLINE search was performed to collect articles addressing prostate cancer and genetic risk factors using key words genetics, prostate cancer and risk. Conclusions. A number of potential genetic risk factors/markers has been identified whichmay in near future contribute to earlier diagnosis of PC. Despite many promising data we have found differing results and therefore we suppose further research should be conducted to achieve more precise conclusion.

Název v anglickém jazyce

Genetic determinant of prostate cancer: A review

Popis výsledku anglicky

Background. In prostate cancer, early detection and appropriate treatment remain key approaches. Genetic studies have revealed gene abnormalities which may be specifically associated with the risk of prostate cancer: changes in genes for the androgen receptor, RNAseL, ELAC2, MSR1, BRCA 1 and 2, HPCX, KLF6, HPC20 and fusion genes, e.g. TMPRSS2-ERG). Despite differing research results from molecular biological studies, these techniques can assist in earlier diagnosis enabling timely initiation of treatment. Methods. MEDLINE search was performed to collect articles addressing prostate cancer and genetic risk factors using key words genetics, prostate cancer and risk. Conclusions. A number of potential genetic risk factors/markers has been identified whichmay in near future contribute to earlier diagnosis of PC. Despite many promising data we have found differing results and therefore we suppose further research should be conducted to achieve more precise conclusion.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FJ - Chirurgie včetně transplantologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Biomedical Papers-Olomouc

ISSN

1213-8118

e-ISSN

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Svazek periodika

155

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

9

Strana od-do

3-10

Kód UT WoS článku

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EID výsledku v databázi Scopus

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