Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138725" target="_blank" >RIV/61989592:15110/12:33138725 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x" target="_blank" >http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/j.1399-0039.2012.01886.x" target="_blank" >10.1111/j.1399-0039.2012.01886.x</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
Popis výsledku v původním jazyce
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies indicated the increased blood levels of proinflammatory interleukin-6 cytokine in schizophrenia. However, only limited studies explored the relationship between excess production and genetic variations of this cytokine in schizophrenia, and the results were controversial. Here, we investigated possible association of the interleukin-6 gene (IL6) rs1800795 (-174G/C) polymorphism with schizophrenia and relationshipbetween this polymorphism and interleukin-6 protein (IL-6) blood levels. This polymorphism was found by other researchers to associate with different transcription rates and different plasma levels of IL-6. A total of 208 unrelated Armenians were genotyped by polymerase chain reaction with sequence-specific primers, and IL-6 levels were assessed by enzyme-linked immunosorbent assay. The IL6 rs1800795 alleles and genotypes in both groups were in Hardy-Weinberg (H-W) equilibrium. We found
Název v anglickém jazyce
Interleukin-6 promoter polymorphism and plasma levels in patients with schizophrenia
Popis výsledku anglicky
Schizophrenia is a severe psychiatric disease with inflammatory component. Several studies indicated the increased blood levels of proinflammatory interleukin-6 cytokine in schizophrenia. However, only limited studies explored the relationship between excess production and genetic variations of this cytokine in schizophrenia, and the results were controversial. Here, we investigated possible association of the interleukin-6 gene (IL6) rs1800795 (-174G/C) polymorphism with schizophrenia and relationshipbetween this polymorphism and interleukin-6 protein (IL-6) blood levels. This polymorphism was found by other researchers to associate with different transcription rates and different plasma levels of IL-6. A total of 208 unrelated Armenians were genotyped by polymerase chain reaction with sequence-specific primers, and IL-6 levels were assessed by enzyme-linked immunosorbent assay. The IL6 rs1800795 alleles and genotypes in both groups were in Hardy-Weinberg (H-W) equilibrium. We found
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Tissue Antigens
ISSN
0001-2815
e-ISSN
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Svazek periodika
80
Číslo periodika v rámci svazku
2
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
136-142
Kód UT WoS článku
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EID výsledku v databázi Scopus
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