Simultaneous up-regulation of matrix metalloproteinases 1, 2, 3, 7, 8, 9 and tissue inhibitor of metalloproteinases 1, 4 in serum of patients with chronic obstructive pulmonary disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33138879" target="_blank" >RIV/61989592:15110/12:33138879 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1111/j.1440-1843.2012.02197.x" target="_blank" >http://dx.doi.org/10.1111/j.1440-1843.2012.02197.x</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/j.1440-1843.2012.02197.x" target="_blank" >10.1111/j.1440-1843.2012.02197.x</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Simultaneous up-regulation of matrix metalloproteinases 1, 2, 3, 7, 8, 9 and tissue inhibitor of metalloproteinases 1, 4 in serum of patients with chronic obstructive pulmonary disease

Popis výsledku v původním jazyce

Background and objectives: Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs) have been implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). However, the majority of reports focus only on single MMPs and limited information about parallel serum expression of MMPs and their antagonists TIMPs exists so far. The aim of this study was, therefore, to investigate serum expression profile of MMP1,2,3,7,8,9,12,13 and TIMP1,2,3,4 in COPD. Methods: We used multiple microsphere technology to assess the serum concentrations of MMP1,2,3,7,8,9 and TIMP1,2,3,4 in COPD patients (n=74) and control subjects (n=20). Subanalysis was performed according to GOLD stage and smoking status. Results: In comparison with control subjects, the elevated concentrations of MMP1,2,3,7,8,9 were observed in serum from COPD patients (p-range: 0.001-0.043). The increased serum concentrations of MMP1,8,9 paralleled the GOLD stage (p-range: 0.002-0.007). Of studie

Název v anglickém jazyce

Simultaneous up-regulation of matrix metalloproteinases 1, 2, 3, 7, 8, 9 and tissue inhibitor of metalloproteinases 1, 4 in serum of patients with chronic obstructive pulmonary disease

Popis výsledku anglicky

Background and objectives: Matrix MetalloProteinases (MMPs) and Tissue Inhibitors of MetalloProteinases (TIMPs) have been implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). However, the majority of reports focus only on single MMPs and limited information about parallel serum expression of MMPs and their antagonists TIMPs exists so far. The aim of this study was, therefore, to investigate serum expression profile of MMP1,2,3,7,8,9,12,13 and TIMP1,2,3,4 in COPD. Methods: We used multiple microsphere technology to assess the serum concentrations of MMP1,2,3,7,8,9 and TIMP1,2,3,4 in COPD patients (n=74) and control subjects (n=20). Subanalysis was performed according to GOLD stage and smoking status. Results: In comparison with control subjects, the elevated concentrations of MMP1,2,3,7,8,9 were observed in serum from COPD patients (p-range: 0.001-0.043). The increased serum concentrations of MMP1,8,9 paralleled the GOLD stage (p-range: 0.002-0.007). Of studie

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/NS10267" target="_blank" >NS10267: Expresní profilování imunologických biomarkerů v různých fázích CHOPN</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Respirology

ISSN

1323-7799

e-ISSN

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Svazek periodika

17

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

1006-1012

Kód UT WoS článku

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EID výsledku v databázi Scopus

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