Drug-induced cholestatic liver injury

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33139127" target="_blank" >RIV/61989592:15110/12:33139127 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Drug-induced cholestatic liver injury

Popis výsledku v původním jazyce

The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half ofall reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the

Název v anglickém jazyce

Drug-induced cholestatic liver injury

Popis výsledku anglicky

The review deals with the probable etiology, diagnostics, classification, most likely causative drugs, risk factors and disease course of drug-induced cholestasis. Cholestatic and mixed forms of drug-induced liver injury (DILI) account for nearly half ofall reported cases. Medications are probably responsible for 2 - 5 % of cases of jaundice requiring hospital admission; moreover, all forms of DILI are currently the most common adverse drug reaction resulting in withdrawal of new drugs from clinical research. Cholestatic syndromes caused by drugs can be divided into acute (bland cholestasis, cholestatic hepatitis and cholangiolitis) and, less frequent, chronic (vanishing bile duct syndrome and extrahepatic biliary obstruction). The etiology seems to be mostly idiosyncratic, with a supposed genetic predisposition. Bile salt export pump (BSEP) is known to be subject to drug inhibition in susceptible patients. Besides rare mutations that have been linked to drug-induced cholestasis, the

Druh

C - Kapitola v odborné knize

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GBP303%2F12%2FG163" target="_blank" >GBP303/12/G163: Centrum interakcí potravních doplňků s léčivy a nutrigenetiky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Bilirubin Chemistry, Regulation and Disorder

ISBN

978-1-62100-911-5

Počet stran výsledku

15

Strana od-do

279-293

Počet stran knihy

323

Název nakladatele

Nova Science Publishers, Inc.

Místo vydání

New York

Kód UT WoS kapitoly

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