BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140001" target="_blank" >RIV/61989592:15110/12:33140001 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022510X12002195?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022510X12002195?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jns.2012.05.008" target="_blank" >10.1016/j.jns.2012.05.008</a>

Jazyk výsledku

angličtina

Název v původním jazyce

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Popis výsledku v původním jazyce

Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age as a covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive activation of bilateral frontoparietal sensorimotor cortical areas, anterior cingulate gyrus, pallidum, thalamus and cerebellum. Effective BoNT-A treatment (W4) resulted in partial reduction of active network volume inmost of the observed areas, whereas BoNT-free data (W11) revealed further volume reduction in the sensorimotor network. On direct comparison, significant activation decreases associated with BoNT-A treatment were located in areas outside the classical sensorimotor system, namely, ipsilesional lateral occipital cortex, supramarginal gyrus and precuneus cortex. On comparison of W4 and W11, no activation increases were found, instead, activation further decreased in ipsilesional insular cortex, contralesional superior frontal gyrus and bilateral frontal pole.

Název v anglickém jazyce

BoNT-A related changes of cortical activity in patients suffering from severe hand paralysis with arm spasticity following ischemic stroke

Popis výsledku anglicky

Investigations were performed to localize and analyze the botulinum toxin (BoNT-A) related changes of cerebral cortex activation in chronic stroke patients suffering from severe hand paralysis with arm spasticity. Effects on task- related cerebral activation were evaluated by functional magnetic resonance imaging (fMRI). Methods: 14 patients (5 males, 9 females,mean age 55.3 years) suffering from upper limb post-stroke spasticity were investigated. The change of armspasticitywas assessed by using the modified Ashworth scale (MAS). FMRI sessionswere performed before (W0), four weeks (W4) and 11 weeks (W11) after BoNT-A application. Patients were scannedwhile performing imaginarymovementwith the impaired hand. Group fMRI analysis included patient age as a covariate. Results: BoNT-A treatmentwas effective in alleviation of armspasticity. Mean MASwas at Week 0: 2.5 (SD 0.53), at Week 4: 1.45 (SD 0.38), at Week 11: 2.32 (SD 0.44). Task-related fMRI prior to the treatment showed extensive activation of bilateral frontoparietal sensorimotor cortical areas, anterior cingulate gyrus, pallidum, thalamus and cerebellum. Effective BoNT-A treatment (W4) resulted in partial reduction of active network volume inmost of the observed areas, whereas BoNT-free data (W11) revealed further volume reduction in the sensorimotor network. On direct comparison, significant activation decreases associated with BoNT-A treatment were located in areas outside the classical sensorimotor system, namely, ipsilesional lateral occipital cortex, supramarginal gyrus and precuneus cortex. On comparison of W4 and W11, no activation increases were found, instead, activation further decreased in ipsilesional insular cortex, contralesional superior frontal gyrus and bilateral frontal pole.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30103 - Neurosciences (including psychophysiology)

Projekt

<a href="/cs/project/NS9920" target="_blank" >NS9920: Změny organizace a aktivace motorického a premotorického kortexu u pacientů se spasticitou po ischemickém iktu v závislosti na léčbě botulotoxinem: fMRI studie</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Neurological Sciences

ISSN

0022-510X

e-ISSN

—

Svazek periodika

319

Číslo periodika v rámci svazku

1-2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

89-95

Kód UT WoS článku

000306246900018

EID výsledku v databázi Scopus

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