A novel sarcoidosis risk locus for europeans on chromosome 11q13.1
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33140029" target="_blank" >RIV/61989592:15110/12:33140029 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >http://dx.doi.org/10.1164/rccm.201204-0708OC</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1164/rccm.201204-0708OC" target="_blank" >10.1164/rccm.201204-0708OC</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
A novel sarcoidosis risk locus for europeans on chromosome 11q13.1
Popis výsledku v původním jazyce
Rationale: Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. Objectives: To identify additionalrisk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genome-wide association scan for these phenotypes. Methods: After quality control, the genome-wide association scan comprised nearly 1.3 million imputed single-nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and 1,575 control subjects. Measurements and Main Results: We identified chromosome 11q13.1 (rs479777) as anovel locus influencing susceptibility to sarcoidosis with genome-wide significance. The marker was significantly associated in three distinct German case-control populations and in an additional German family sample with odds ratios rang
Název v anglickém jazyce
A novel sarcoidosis risk locus for europeans on chromosome 11q13.1
Popis výsledku anglicky
Rationale: Sarcoidosis is a complex inflammatory disease with a heterogeneous clinical picture. Among others, an acute and chronic clinical course can be distinguished, for which specific genetic risk factors are known. Objectives: To identify additionalrisk loci for sarcoidosis and its acute and chronic subforms, we analyzed imputed data from a genome-wide association scan for these phenotypes. Methods: After quality control, the genome-wide association scan comprised nearly 1.3 million imputed single-nucleotide polymorphisms based on an Affymetrix 6.0 Gene Chip dataset of 564 German sarcoidosis cases, including 176 acute and 354 chronic cases and 1,575 control subjects. Measurements and Main Results: We identified chromosome 11q13.1 (rs479777) as anovel locus influencing susceptibility to sarcoidosis with genome-wide significance. The marker was significantly associated in three distinct German case-control populations and in an additional German family sample with odds ratios rang
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EC - Imunologie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2012
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
American Journal of Respiratory and Critical Care Medicine
ISSN
1073-449X
e-ISSN
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Svazek periodika
186
Číslo periodika v rámci svazku
9
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
9
Strana od-do
877-885
Kód UT WoS článku
000311128300014
EID výsledku v databázi Scopus
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