NQO1 expression correlates inversely with NF kappa B activation in human breast cancer

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33141807" target="_blank" >RIV/61989592:15110/12:33141807 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s10549-011-1629-5" target="_blank" >http://dx.doi.org/10.1007/s10549-011-1629-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10549-011-1629-5" target="_blank" >10.1007/s10549-011-1629-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

NQO1 expression correlates inversely with NF kappa B activation in human breast cancer

Popis výsledku v původním jazyce

NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NF kappa B-mediated pathways. We have previously found that homozygous missense variant NQO1*2 (rs1800566) predicts poor survival among breast cancer patients, particularly after anthracycline-based adjuvant chemotherapy. Here, we investigated NQO1 and NF kappa B protein expression and global gene expression profiles in breast tumors with correlation to tumor characteristics and survival after adjuvant chemotherapy. We used immunohistochemical analysis of tissue microarrays to study NQO1 and NF kappa B expression in two series of tumors: 1000 breast tumors unselected for treatment and 113 from a clinical trial comparing chemotherapy regimens after anthracycline treatment in advanced breast cancer. We used gene expression arrays to define genes co-expressed with NQO1 and NF kappa B. NQO1 and nuclear NF kappa B were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0

Název v anglickém jazyce

NQO1 expression correlates inversely with NF kappa B activation in human breast cancer

Popis výsledku anglicky

NQO1 participates in cellular defense against oxidative stress and regulates apoptosis via p53- and NF kappa B-mediated pathways. We have previously found that homozygous missense variant NQO1*2 (rs1800566) predicts poor survival among breast cancer patients, particularly after anthracycline-based adjuvant chemotherapy. Here, we investigated NQO1 and NF kappa B protein expression and global gene expression profiles in breast tumors with correlation to tumor characteristics and survival after adjuvant chemotherapy. We used immunohistochemical analysis of tissue microarrays to study NQO1 and NF kappa B expression in two series of tumors: 1000 breast tumors unselected for treatment and 113 from a clinical trial comparing chemotherapy regimens after anthracycline treatment in advanced breast cancer. We used gene expression arrays to define genes co-expressed with NQO1 and NF kappa B. NQO1 and nuclear NF kappa B were expressed in 83% and 11% of breast tumors, and correlated inversely (P = 0

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FD - Onkologie a hematologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BREAST CANCER RESEARCH AND TREATMENT

ISSN

0167-6806

e-ISSN

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Svazek periodika

132

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

955-968

Kód UT WoS článku

000303379800019

EID výsledku v databázi Scopus

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