Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F12%3A33143017" target="_blank" >RIV/61989592:15110/12:33143017 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-94-007-2993-3_2" target="_blank" >http://dx.doi.org/10.1007/978-94-007-2993-3_2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-94-007-2993-3_2" target="_blank" >10.1007/978-94-007-2993-3_2</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation

Popis výsledku v původním jazyce

Embryonic stem cells (ESCs) have an unusual cell cycle structure with a short G1 phase and with the largest proportion of cells in the S phase. During differentiation, the ESC cycle is readily remodeled and a prominent G1 phase is established. Recently,prolongation of G1 phase has been shown to be sufficient to induce ESC differentiation and, on the other hand, remodeling of cell cycle to an ESC-like cell cycle has been found to be a crucial and rate-limiting step in the process of reprogramming of differentiated cells to induced pluripotent stem cells. The specific structure of ESC cycle has been suggested to be a general requirement for pluripotency and self-renewal and existence of several links between cell cycle machinery and core pluripotency factors has been proposed.

Název v anglickém jazyce

Self-renewal of Embryonic Stem Cells: Cell Cycle Regulation

Popis výsledku anglicky

Embryonic stem cells (ESCs) have an unusual cell cycle structure with a short G1 phase and with the largest proportion of cells in the S phase. During differentiation, the ESC cycle is readily remodeled and a prominent G1 phase is established. Recently,prolongation of G1 phase has been shown to be sufficient to induce ESC differentiation and, on the other hand, remodeling of cell cycle to an ESC-like cell cycle has been found to be a crucial and rate-limiting step in the process of reprogramming of differentiated cells to induced pluripotent stem cells. The specific structure of ESC cycle has been suggested to be a general requirement for pluripotency and self-renewal and existence of several links between cell cycle machinery and core pluripotency factors has been proposed.

Druh

C - Kapitola v odborné knize

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Stem Cells and Cancer Stem Cells

ISBN

978-94-007-2992-6

Počet stran výsledku

10

Strana od-do

11-20

Počet stran knihy

448

Název nakladatele

Springer Netherlands

Místo vydání

Dordrecht

Kód UT WoS kapitoly

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