Efficacy and safety of erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis - a pilot study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33145985" target="_blank" >RIV/61989592:15110/13:33145985 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11120/13:43907937

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy and safety of erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis - a pilot study

Popis výsledku v původním jazyce

Background: Erdosteine was originally developed as a mucolytic agent. It is a multimechanism substance with anti-bacterial,anti-oxidant, and most importantly anti-inflammatory effects. Given similar mechanisms of action (suppression of cytokines, includingtumor necrosis factor alfa), it could become a reasonable alternative to currently used treatments with macrolides or steroids. Objective: To assess efficacy and safety of erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Methodology: A prospective non-interventional post-authorisation study comparing patients treated with erdosteine only or thecombination of erdosteine and nasal corticosteroid spray for CRSwNP. The end-points were pre- and post-treatment changes inendoscopic score and subjective evaluation of CRSwNP related symptoms using a 22-item Sinonasal Outcome Test questionnaire. Patients underwent nasal endoscopy and filled the questionnaire before and after the treatment. Results: No patient

Název v anglickém jazyce

Efficacy and safety of erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis - a pilot study

Popis výsledku anglicky

Background: Erdosteine was originally developed as a mucolytic agent. It is a multimechanism substance with anti-bacterial,anti-oxidant, and most importantly anti-inflammatory effects. Given similar mechanisms of action (suppression of cytokines, includingtumor necrosis factor alfa), it could become a reasonable alternative to currently used treatments with macrolides or steroids. Objective: To assess efficacy and safety of erdosteine in the treatment of chronic rhinosinusitis with nasal polyposis (CRSwNP). Methodology: A prospective non-interventional post-authorisation study comparing patients treated with erdosteine only or thecombination of erdosteine and nasal corticosteroid spray for CRSwNP. The end-points were pre- and post-treatment changes inendoscopic score and subjective evaluation of CRSwNP related symptoms using a 22-item Sinonasal Outcome Test questionnaire. Patients underwent nasal endoscopy and filled the questionnaire before and after the treatment. Results: No patient

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Rhinology

ISSN

0300-0729

e-ISSN

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Svazek periodika

51

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

323-327

Kód UT WoS článku

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EID výsledku v databázi Scopus

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