Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146042" target="_blank" >RIV/61989592:15110/13:33146042 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/13:#0000559

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor.

Popis výsledku v původním jazyce

Introduction: Recent research suggests that the multiplicity in recurrent pleomorphic adenoma (PA) might result from migration of its cells through lymphatics. This process in malignancies is mediated by vascular endothelial factors C and D (VEGF-C/D). Authors present very first study investigating immunohistoexpression of VEGF-C/D and lymphatic vessel density (LVD) in PA. Materials&Methods: Six non-recurrent, 4 primary-to-recur and 10 recurrent PAs were stained. The histoscore was calculated as a sum of staining intensity (0=absent to 3=strong) and the percentage of positive tumor cells (scored as 0 (0-19 %), 1 (20-39%), 2 (40-50%) and 3 (60-100%)). Intra- and peritumoral LVD was assessed using D2-40 antibody. Results: All but one sample were VEGF-C negative. The differences in VEGF-D histoscore among non-recurrent, primary-to-recur, and recurrent PAs were not significant (p}0.05). The VEGF-D histoscore didn't correlate with peritumoral LVD (p}0.05). Our study revealed a significant d

Název v anglickém jazyce

Insignificant differences in VEGF-C/D immunohistoexpression and lymphatic microvessel density between primary and recurrent salivary pleomorphic adenoma do not support the role of lymphangiogenesis in local spread of this tumor.

Popis výsledku anglicky

Introduction: Recent research suggests that the multiplicity in recurrent pleomorphic adenoma (PA) might result from migration of its cells through lymphatics. This process in malignancies is mediated by vascular endothelial factors C and D (VEGF-C/D). Authors present very first study investigating immunohistoexpression of VEGF-C/D and lymphatic vessel density (LVD) in PA. Materials&Methods: Six non-recurrent, 4 primary-to-recur and 10 recurrent PAs were stained. The histoscore was calculated as a sum of staining intensity (0=absent to 3=strong) and the percentage of positive tumor cells (scored as 0 (0-19 %), 1 (20-39%), 2 (40-50%) and 3 (60-100%)). Intra- and peritumoral LVD was assessed using D2-40 antibody. Results: All but one sample were VEGF-C negative. The differences in VEGF-D histoscore among non-recurrent, primary-to-recur, and recurrent PAs were not significant (p}0.05). The VEGF-D histoscore didn't correlate with peritumoral LVD (p}0.05). Our study revealed a significant d

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FF - ORL, oftalmologie, stomatologie

OECD FORD obor

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Projekt

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Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Virchows Archiv

ISSN

0945-6317

e-ISSN

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Svazek periodika

463

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

1

Strana od-do

115

Kód UT WoS článku

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EID výsledku v databázi Scopus

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