Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146094" target="_blank" >RIV/61989592:15110/13:33146094 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1007/s13105-012-0222-7" target="_blank" >http://dx.doi.org/10.1007/s13105-012-0222-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s13105-012-0222-7" target="_blank" >10.1007/s13105-012-0222-7</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations
Popis výsledku v původním jazyce
The question whether A3 adenosine receptor (A3AR) agonists, N6-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-adenosine-5?-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations withor without the involvement of A3AR has been a controversial issue for a long time. The initial findings suggesting that A3AR plays a crucial role in the induction of cell death upon treatment with micromolar concentrations of IB-MECA or Cl-IB-MECA were revised, however, the direct and unequivocal evidence is still missing. Therefore, the sensitivity of CHO cells transfected with human recombinant A3AR (A3-CHO) and their counter partner wild type CHO cells, which do not express any of adenosine receptors, to micromolar concentrations of IB-MECA and Cl-IB-MECA was studied. We observed that IB-MECA and Cl-IB-MECA exhibited a strong inhibitory effect on cell proliferation due to the blockage of cell cycle progression at G1/S and G2/M transi
Název v anglickém jazyce
Effects of synthetic A3 adenosine receptor agonists on cell proliferation and viability are receptor independent at micromolar concentrations
Popis výsledku anglicky
The question whether A3 adenosine receptor (A3AR) agonists, N6-(3-iodobenzyl)-adenosine-5'-N- methyluronamide (IB-MECA) and 2-chloro-N6-(3-iodobenzyl)-adenosine-5?-N-methyluronamide (Cl-IB-MECA), could exert cytotoxic effects at high concentrations withor without the involvement of A3AR has been a controversial issue for a long time. The initial findings suggesting that A3AR plays a crucial role in the induction of cell death upon treatment with micromolar concentrations of IB-MECA or Cl-IB-MECA were revised, however, the direct and unequivocal evidence is still missing. Therefore, the sensitivity of CHO cells transfected with human recombinant A3AR (A3-CHO) and their counter partner wild type CHO cells, which do not express any of adenosine receptors, to micromolar concentrations of IB-MECA and Cl-IB-MECA was studied. We observed that IB-MECA and Cl-IB-MECA exhibited a strong inhibitory effect on cell proliferation due to the blockage of cell cycle progression at G1/S and G2/M transi
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CE - Biochemie
OECD FORD obor
—
Návaznosti výsledku
Projekt
—
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Journal of Physiology and Biochemistry
ISSN
1138-7548
e-ISSN
—
Svazek periodika
69
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
ES - Španělské království
Počet stran výsledku
13
Strana od-do
405-417
Kód UT WoS článku
000322730300006
EID výsledku v databázi Scopus
—