Complement system in SLE as a target for antibodies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F13%3A33146837" target="_blank" >RIV/61989592:15110/13:33146837 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/13:#0000483

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Complement system in SLE as a target for antibodies

Popis výsledku v původním jazyce

SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstaces, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical disease activity and in particular renal involvement. In the presence of high titers of anti-C1q antibodies also the levels of C1q and C3 and C4 complements of the complement system are also usually low. The presence of the anti-C1q antibodies is not limited or specific just for SLE or lupus nephritis. For the first time, they were described in HUVS (Hypocomplementemic Urticarial Vasculitis Syndrome), later in Felty's syndrome, rheumatoid vasculitis, hepatitis C, poststreptococcal glomerulonephritis or aging population.

Název v anglickém jazyce

Complement system in SLE as a target for antibodies

Popis výsledku anglicky

SLE is characterized by overproduction of various types of autoantibodies. Under certain circumstaces, antibodies targeting some of the neoepitopes of the complement system can be seen. The most studied among antibodies directed against a component of the complement system is anti-C1q. Anti-C1q antibodies are present in approximately one third of the patients with lupus, who often have high clinical disease activity and in particular renal involvement. In the presence of high titers of anti-C1q antibodies also the levels of C1q and C3 and C4 complements of the complement system are also usually low. The presence of the anti-C1q antibodies is not limited or specific just for SLE or lupus nephritis. For the first time, they were described in HUVS (Hypocomplementemic Urticarial Vasculitis Syndrome), later in Felty's syndrome, rheumatoid vasculitis, hepatitis C, poststreptococcal glomerulonephritis or aging population.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FE - Ostatní obory vnitřního lékařství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Current Rheumatology Reviews

ISSN

1573-3971

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

34-44

Kód UT WoS článku

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EID výsledku v databázi Scopus

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