2-[18F]fluoro-2-deoxy- D -glucose positron emission tomography/ computed tomography examination in patients with chronic lymphocytic leukemia may reveal Richter transformation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33145755" target="_blank" >RIV/61989592:15110/14:33145755 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00098892:_____/14:#0000660

Výsledek na webu

<a href="http://dx.doi.org/10.3109/10428194.2013.802313" target="_blank" >http://dx.doi.org/10.3109/10428194.2013.802313</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3109/10428194.2013.802313" target="_blank" >10.3109/10428194.2013.802313</a>

Jazyk výsledku

angličtina

Název v původním jazyce

2-[18F]fluoro-2-deoxy- D -glucose positron emission tomography/ computed tomography examination in patients with chronic lymphocytic leukemia may reveal Richter transformation

Popis výsledku v původním jazyce

The signifi cance of positron emission tomography/computed tomography (PET/CT) in chronic lymphocytic leukemia (CLL) has not yet been systematically studied. This prospective study was aimed at assessing the benefi t of PET/CT in patients with newly diagnosed or relapsed CLL and Richter transformation (RT). PET/CT examination was performed in 23 patients with newly diagnosed disease, 13 with relapsed disease and eight with suspected or histopathologically confi rmed RT. In all patients, the maximum standardized uptake value (SUV max ) was calculated. The median SUV max was 3.4 (range: 1.5 – 6.3) and 3.1 (range: 1.2 – 5.9) in newly diagnosed and relapsed patients, respectively. The median SUV max of patients with suspected or confi rmed RT reached 16.5 (range: 7.2 – 25.3), a value diff erent from that of the previous groups ( p 0.001). 2-[18F]fl uoro- 2-deoxy- D -glucose ( 18 F-FDG) PET/CT revealed infl ammatory lesions in seven patients (16%) and synchronous tumors in two newly diagnosed patients. 18 F-FDG PET/CT may be a benefi cial imaging method when used in individuals with CLL and suspected RT.

Název v anglickém jazyce

2-[18F]fluoro-2-deoxy- D -glucose positron emission tomography/ computed tomography examination in patients with chronic lymphocytic leukemia may reveal Richter transformation

Popis výsledku anglicky

The signifi cance of positron emission tomography/computed tomography (PET/CT) in chronic lymphocytic leukemia (CLL) has not yet been systematically studied. This prospective study was aimed at assessing the benefi t of PET/CT in patients with newly diagnosed or relapsed CLL and Richter transformation (RT). PET/CT examination was performed in 23 patients with newly diagnosed disease, 13 with relapsed disease and eight with suspected or histopathologically confi rmed RT. In all patients, the maximum standardized uptake value (SUV max ) was calculated. The median SUV max was 3.4 (range: 1.5 – 6.3) and 3.1 (range: 1.2 – 5.9) in newly diagnosed and relapsed patients, respectively. The median SUV max of patients with suspected or confi rmed RT reached 16.5 (range: 7.2 – 25.3), a value diff erent from that of the previous groups ( p 0.001). 2-[18F]fl uoro- 2-deoxy- D -glucose ( 18 F-FDG) PET/CT revealed infl ammatory lesions in seven patients (16%) and synchronous tumors in two newly diagnosed patients. 18 F-FDG PET/CT may be a benefi cial imaging method when used in individuals with CLL and suspected RT.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Leukemia &amp; Lymphoma

ISSN

1042-8194

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

314-319

Kód UT WoS článku

000330733100015

EID výsledku v databázi Scopus

2-s2.0-84899086491